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LY2784544 (Gandotinib)

JAK 抑制剂

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产品目录号: A10546


产品名 目录号 价格 数量
LY2784544 5mg A10546-5
¥ 900.00
LY2784544 10mg A10546-10
¥ 1,600.00
LY2784544 25mg A10546-25
¥ 5,500.00
LY2784544 100mg A10546-100
¥ 16,000.00
LY2784544 10mM * 1mL in DMSO A10546-10mM-D
¥ 1,440.00



LY2784544 is identified as being highly selective for JAK2-V617F and has advanced into human clinical trials for the treatment of several myeloproliferative disorders.

LY2784544 (Gandotinib)




顾客使用 Adooq 产品发表的高质量科研文献

Chemical Information

目录号 A10546
Mechanism of action Inhibitor
分子量 469.9
化学分子式 C23H25ClFN7O
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 1229236-86-5
Synonyms N/A
化学名称 3-[(4-Chloro-2-fluorophenyl)methyl]-2-methyl-N-(5-methyl-1H-pyrazol-3-yl)-8-(4-morpholinylmethyl)imidazo[1,2-b]pyridazin-6-amine


LY2784544 is identified as being highly selective for JAK2-V617F and has advanced into human clinical trials for the treatment of several myeloproliferative disorders.
Target Value
JAK2(V617F)ki: 0.245nM
JAK2ki: 0.288nM
JAK2IC50: 2.52nM
FLT3IC50: 4nM
JAK1IC50: 19.8nM
FLT4IC50: 25nM
FGFR2IC50: 32nM
TYK2IC50: 44nM
JAK3IC50: 48.0nM
TrkBIC50: 95nM
FGFR3IC50: 106nM
KDRIC50: 109nM
ALKIC50: 138nM
MUSKIC50: 147nM
AuroraAIC50: 168nM
MAP3K9IC50: 299nM


Solubility (25°C)* In vitro DMSO 94 mg/mL (200.02 mM)
Water <1 mg/mL (<1 mM)
Ethanol 9 mg/mL (19.15 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.


Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.28 mL 106.41 mL 212.81mL
0.5 mM 4.26 mL 21.28 mL 42.56 mL
1 mM 2.13 mL 10.64 mL 21.28 mL
5 mM 0.43 mL 2.13 mL 4.26 mL

*The above data is based on the productmolecular weight 469.9 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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