LY2811376
目录号: A11776
BACE1 抑制剂
LY2811376 是首个口服非肽类 BACE1 抑制剂，在动物中产生显著的 Aβ 降低效果。
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生物活性
| Discription | LY2811376 is the first orally available non-peptidic BACE1 inhibitor that produces profound Aβ-lowering effects in animals. | |||||
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产品信息
| 目录号 | A11776 |
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| 分子式 | C15H14F2N4S |
| 分子量 | 320.4 |
| CAS号 | 1194044-20-6 |
| SMILES | C[C@]1(CCSC(=N1)N)C2=C(C=C(C(=C2)C3=CN=CN=C3)F)F |
| 其他名称 | LY 2811376, LY-2811376 |
| 储存条件 | Store lyophilized at -20ºC, keep desiccated. |
溶解性数据
| In vitro (25°C) | DMSO | 16 mg/mL (49.94 mM) | |
| Water | Insoluble | ||
| Ethanol | 63 mg/mL (196.65 mM) | ||
| In vivo | 30% PEG400+0.5% Tween80+5% propylene glycol | 28 mg/mL | |
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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Preparing Stock Solutions
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 31.21 mL | 156.05 mL | 312.11 mL |
| 0.5 mM | 6.24 mL | 31.21 mL | 62.42 mL |
| 1 mM | 3.12 mL | 15.61 mL | 31.21 mL |
| 5 mM | 0.62 mL | 3.12 mL | 6.24 mL |
Useful Calculator
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2
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| 购买 1194044-20-6 | 1194044-20-6 供应商 | 1194044-20-6 花费 | 1194044-20-6 生产商 | 订购 1194044-20-6 | 1194044-20-6 代理商