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LY2811376是第一种可口服的非肽类BACE1抑制剂，可在动物体内产生显着的Aβ降低作用。
靶点信息
| BACE1 | Aβ | |||
| 239 nM-249 nM | ~300 nM(EC50) |
| In vitro (25°C) | DMSO | 16 mg/mL (49.94 mM) | |
| Water | Insoluble | ||
| Ethanol | 63 mg/mL (196.65 mM) | ||
| In vivo | 30% PEG400+0.5% Tween80+5% propylene glycol | 28 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 31.21 mL | 156.05 mL | 312.11 mL |
| 0.5 mM | 6.24 mL | 31.21 mL | 62.42 mL |
| 1 mM | 3.12 mL | 15.61 mL | 31.21 mL |
| 5 mM | 0.62 mL | 3.12 mL | 6.24 mL |
*The above data is based on the productmolecular weight 320.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A11776 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 320.4 |
| Formula | C15H14F2N4S |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1194044-20-6 |
| Synonyms | LY 2811376, LY-2811376 |
| SMILES | C[C@]1(CCSC(=N1)N)C2=C(C=C(C(=C2)C3=CN=CN=C3)F)F |
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