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BACE1 抑制剂

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产品目录号: A11776


产品名 目录号 价格 数量
LY2811376 5mg A11776-5
¥ 900.00
LY2811376 10mg A11776-10
¥ 1,600.00
LY2811376 50mg A11776-50
¥ 5,000.00
LY2811376 100mg A11776-100
¥ 8,500.00
LY2811376 10mM * 1mL in DMSO A11776-10mM-D
¥ 1,170.00



LY2811376 is the first orally available non-peptidic BACE1 inhibitor that produces profound Aβ-lowering effects in animals.





顾客使用 Adooq 产品发表的高质量科研文献

Chemical Information

目录号 A11776
Mechanism of action Inhibitor
分子量 320.4
化学分子式 C15H14F2N4S
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 1194044-20-6
Synonyms LY 2811376, LY-2811376
SMILES code C[C@]1(CCSC(=N1)N)C2=C(C=C(C(=C2)C3=CN=CN=C3)F)F
化学名称 (S)-4-(2,4-difluoro-5-pyrimidin-5-yl-phenyl)-4-methyl-5,6-dihydro-4H-[1,3]thiazin-2-ylamine


LY2811376 is the first orally available non-peptidic BACE1 inhibitor that produces profound Aβ-lowering effects in animals.
239 nM-249 nM~300 nM(EC50)


Solubility (25°C) * In vitro DMSO 16 mg/mL (49.94 mM)
Water <1 mg/mL (<1 mM)
Ethanol 64 mg/mL (199.77 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.


Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 31.21 mL 156.05 mL 312.11mL
0.5 mM 6.24 mL 31.21 mL 62.42 mL
1 mM 3.12 mL 15.61 mL 31.21 mL
5 mM 0.62 mL 3.12 mL 6.24 mL

*The above data is based on the productmolecular weight 320.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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