LY2835219 methanesulfonate

Name: LY2835219 methanesulfonate
SKU: A16386
Price: 175 CNY
Rating: 5 (1 reviews)

目录号: A16386

CDK4/6 抑制剂

1 篇发表文献

LY2835219 是一种针对 CDK4 和 CDK6 的强效且选择性的抑制剂，在无细胞试验中，其 IC50 分别为 2 nM 和 10 nM。目前处于第三阶段临床试验。

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Grouped product items
规格	价格	库存
2mg	¥175.00	现货
5mg	¥315.00	现货
10mg	¥455.00	现货
25mg	¥560.00	现货
50mg	¥630.00	现货
100mg	¥840.00	现货
200mg	¥1,050.00	现货
500mg	¥2,520.00	现货
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Data Sheet

SDS

顾客使用 Adooq 产品发表的高质量科研文献

Adooq用户使用LY2835219 methanesulfonate发表的1篇文献

Shuso Takeda, .et al. , Fundam Toxicol Sci, 2021, 8(3):75-80

生物活性

Discription

LY2835219 is a potent and selective inhibitor of CDK4 and CDK6 with IC50 of 2 nM and 10 nM in cell-free assays, respectively. Phase 3.

Targets

Target	Value

Cell Research

Cell Line	Type	Value	Description	References

产品信息

目录号	A16386
分子式	C27H32F2N8.CH4O3S
分子量	602.7
CAS号	1231930-82-7
SMILES	CCN1CCN(CC1)CC2=CN=C(C=C2)NC3=NC=C(C(=N3)C4=CC5=C(C(=C4)F)N=C(N5C(C)C)C)F.CS(=O)(=O)O
其他名称	Abemaciclib
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro (25°C)	DMSO	81 mg/mL (134.39 mM)
	Water	97 mg/mL (160.94 mM)
	Ethanol	23 mg/mL
In vivo	water	95 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	16.59 mL	82.96 mL	165.92 mL
0.5 mM	3.32 mL	16.59 mL	33.18 mL
1 mM	1.66 mL	8.3 mL	16.59 mL
5 mM	0.33 mL	1.66 mL	3.32 mL

Useful Calculator

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Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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* Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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