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LY2835219 methanesulfonate

LY2835219 methanesulfonate

Name: LY2835219 methanesulfonate
SKU: A16386

目录号: A16386

CDK4/6 抑制剂

LY2835219 methanesulfonate Chemical Structure

CAS NO. 1231930-82-7

LY2835219是一种有效且选择性的CDK4和CDK6抑制剂，在无细胞试验中的IC50分别为2 nM和10 nM。

库存：现货

规格	价格	数量
5 mg	￥ 500.00
10 mg	￥ 900.00
50 mg	￥ 1,100.00

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生物活性

LY2835219是一种有效且选择性的CDK4和CDK6抑制剂，在无细胞试验中的IC50分别为2 nM和10 nM。

溶解度 *

In vitro (25°C)	DMSO	81 mg/mL (134.39 mM)
	Water	97 mg/mL (160.94 mM)
	Ethanol	23 mg/mL
In vivo	water	95 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	16.59 mL	82.96 mL	165.92 mL
0.5 mM	3.32 mL	16.59 mL	33.18 mL
1 mM	1.66 mL	8.3 mL	16.59 mL
5 mM	0.33 mL	1.66 mL	3.32 mL

*The above data is based on the productmolecular weight 602.7. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A16386
作用机制	Inhibitor (抑制剂)
M. Wt	602.7
Formula	C27H32F2N8.CH4O3S
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	1231930-82-7
Synonyms	Abemaciclib
SMILES	CCN1CCN(CC1)CC2=CN=C(C=C2)NC3=NC=C(C(=N3)C4=CC5=C(C(=C4)F)N=C(N5C(C)C)C)F.CS(=O)(=O)O