abemaciclib (LY2835219)

Name: abemaciclib (LY2835219)
SKU: A12989
Price: 280 CNY
Rating: 5 (10 reviews)

目录号: A12989

CDK4/6 抑制剂

10 篇发表文献

abemaciclib (LY2835219) 是一种口服可用的细胞周期依赖性激酶（CDK）抑制剂，针对 CDK4 (cyclin D1) 和 CDK6 (cyclin D3) 细胞周期通路，具有潜在的抗肿瘤活性。

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Grouped product items
规格	价格	库存
5mg	¥280.00	现货
10mg	¥350.00	现货
25mg	¥490.00	现货
50mg	¥630.00	现货
100mg	¥805.00	现货
200mg	¥1,050.00	现货
500mg	¥1,960.00	现货
1g	¥3,640.00	现货
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重要通知：仅供研究使用。我们不向患者销售。

Data Sheet

SDS

顾客使用 Adooq 产品发表的高质量科研文献

Adooq用户使用abemaciclib (LY2835219)发表的10篇文献

Che-Yuan Hsu, .et al. , Br J Cancer, 2024, Sep;131(5):944-953 PMID: 38987365

Yukinori Ozaki, .et al. , Am J Cancer Res, 2023, Oct 15;13(10):4931-4943 PMID: 37970362

Elaheh S Abutorabi, .et al. , Mol Biol Rep, 2023, May;50(5):4073-4082 PMID: 36877344

Yoshinori Tanaka, .et al. , Biochem Biophys Res Commun, 2022, Jul 23;614:191-97 PMID: 35598430

Sumire Suzuki, .et al. , Oncol Rep, 2022, Feb;47(2):40 PMID: 34958115

Kana Nakatani, .et al. , Int J Hematol, 2020, Oct 17 PMID: 33068248

Ryohei Ogata, .et al. , Breast Cancer, 2020, Aug 28 PMID: 32860163

Elaheh Seyed Abutorabi, .et al. , Rep Biochem Mol Biol, 2020, Jan; 8(4): 438-445 PMID: 32582803

Hidemasa Matsuo, .et al. , Blood Adv, 2018, Nov 13; 2(21): 2879-2889 PMID: 30381403

Iriyama N, .et al. , Leuk Lymphoma, 2018, Jun;59(6):1439-1450 PMID: 28918692

生物活性

Discription

abemaciclib (LY2835219) is an orally available cyclin-dependent kinase (CDK) inhibitor that targets the CDK4 (cyclin D1) and CDK6 (cyclin D3) cell cycle pathway, with potential antineoplastic activity.

Targets

Target	Value

Cell Research

Cell Line	Type	Value	Description	References

产品信息

目录号	A12989
分子式	C27H32F2N8
分子量	506.59
CAS号	1231929-97-7
SMILES	CCN1CCN(CC1)CC2=CN=C(C=C2)NC3=NC=C(C(=N3)C4=CC5=C(C(=C4)F)N=C(N5C(C)C)C)F
其他名称	LY 2835219, LY-2835219
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro	DMSO	6 mg/mL (11.84 mM)
	Water	Insoluble
	Ethanol	8 mg/mL (15.79 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	19.74 mL	98.7 mL	197.4 mL
0.5 mM	3.95 mL	19.74 mL	39.48 mL
1 mM	1.97 mL	9.87 mL	19.74 mL
5 mM	0.39 mL	1.97 mL	3.95 mL

Useful Calculator

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Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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* Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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