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LY2835219 (abemaciclib)

促销

CDK4/6 抑制剂

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产品目录号: A12989

库存状态:中国现货中国现货

产品名 目录号 价格 数量
LY2835219 5mg A12989-5
¥ 600.00
LY2835219 10mg A12989-10
¥ 900.00
LY2835219 25mg A12989-25
¥ 1,400.00
LY2835219 50mg A12989-50
¥ 1,800.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

LY2835219 is an orally available cyclin-dependent kinase (CDK) inhibitor that targets the CDK4 (cyclin D1) and CDK6 (cyclin D3) cell cycle pathway, with potential antineoplastic activity.

LY2835219 (abemaciclib)

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顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 LY2835219 (abemaciclib) 发表的文献 (2)
  • Hidemasa Matsuo, .et al. Recurrent CCND3 mutations in MLL-rearranged acute myeloid leukemia, Blood Adv, 2018, Nov 13; 2(21): 2879每2889 PMID: 30381403
  • Iriyama N, .et al. The cyclin-dependent kinase 4/6 inhibitor, abemaciclib, exerts dose-dependent cytostatic and cytocidal effects and induces autophagy in multiple myeloma cells, Leuk Lymphoma, 2018, Jun;59(6):1439-1450 PMID: 28918692

Chemical Information

目录号 A12989
Mechanism of action Inhibitor
分子量 506.59
化学分子式 C27H32F2N8
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 1231929-97-7
Synonyms LY 2835219, LY-2835219
SMILES code CCN1CCN(CC1)CC2=CN=C(C=C2)NC3=NC=C(C(=N3)C4=CC5=C(C(=C4)F)N=C(N5C(C)C)C)F
化学名称 2-Pyrimidinamine, N-[5-[(4-ethyl-1-piperazinyl)methyl]-2-pyridinyl]-5-fluoro-4-[4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl]

生物活性

Description
LY2835219 is an orally available cyclin-dependent kinase (CDK) inhibitor that targets the CDK4 (cyclin D1) and CDK6 (cyclin D3) cell cycle pathway, with potential antineoplastic activity.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.74 mL 98.7 mL 197.4mL
0.5 mM 3.95 mL 19.74 mL 39.48 mL
1 mM 1.97 mL 9.87 mL 19.74 mL
5 mM 0.39 mL 1.97 mL 3.95 mL

*The above data is based on the productmolecular weight 506.59. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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