LY2857785
目录号: A15823
CDK9 抑制剂
LY2857785 是一种强效且选择性的 CDK9 抑制剂;显著降低 RNAP II CTD 磷酸化,并显著降低 MCL1 蛋白水平,从而在多种白血病和实体瘤细胞系中引发凋亡。
| Discription | LY2857785 is a potent and selective CDK9 inhibitor; significantly reduces RNAP II CTD phosphorylation and dramatically decreases MCL1 protein levels to result in apoptosis in a variety of leukemia and solid tumor cell lines. | ||
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| 目录号 | A15823 |
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| 分子式 | C26H36N6O |
| 分子量 | 448.6 |
| CAS号 | 1619903-54-6 |
| SMILES | CC(C)C1=C2C=C(C=CC2=NN1C)C3=NC(=NC=C3)NC4CCC(CC4)NC5CCOCC5 |
| 其他名称 | LY-2857785, LY 2857785 |
| 储存条件 | Store lyophilized at -20ºC, keep desiccated. |
| In vitro | DMSO | 22 mg/mL (49.04 mM) | |
| Water | Insoluble | ||
| Ethanol | 40 mg/mL (89.16 mM) | ||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 22.29 mL | 111.46 mL | 222.92 mL |
| 0.5 mM | 4.46 mL | 22.29 mL | 44.58 mL |
| 1 mM | 2.23 mL | 11.15 mL | 22.29 mL |
| 5 mM | 0.45 mL | 2.23 mL | 4.46 mL |
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2