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LY2857785

促销

CDK9 抑制剂

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产品目录号: A15823

库存状态:中国现货中国现货

产品名 目录号 价格 数量
LY2857785 5mg A15823-5
¥ 3,000.00
LY2857785 10mg A15823-10
¥ 5,500.00
LY2857785 25mg A15823-25
¥ 12,000.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

LY2857785 is a potent and selective CDK9 inhibitor; significantly reduces RNAP II CTD phosphorylation and dramatically decreases MCL1 protein levels to result in apoptosis in a variety of leukemia and solid tumor cell lines.

LY2857785

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Chemical Information

目录号 A15823
Mechanism of action Inhibitor
分子量 448.6
化学分子式 C26H36N6O
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 1619903-54-6
Synonyms LY-2857785, LY 2857785
SMILES code CC(C)C1=C2C=C(C=CC2=NN1C)C3=NC(=NC=C3)NC4CCC(CC4)NC5CCOCC5
化学名称 (1r,4r)-N1-(4-(3-isopropyl-2-methyl-2H-indazol-5-yl)pyrimidin-2-yl)-N4-(tetrahydro-2H-pyran-4-yl)cyclohexane-1,4-diamine

生物活性

Description
LY2857785 is a potent and selective CDK9 inhibitor; significantly reduces RNAP II CTD phosphorylation and dramatically decreases MCL1 protein levels to result in apoptosis in a variety of leukemia and solid tumor cell lines.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.29 mL 111.46 mL 222.92mL
0.5 mM 4.46 mL 22.29 mL 44.58 mL
1 mM 2.23 mL 11.15 mL 22.29 mL
5 mM 0.45 mL 2.23 mL 4.46 mL

*The above data is based on the productmolecular weight 448.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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