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LY3023414

PI3K/mTOR Dual 抑制剂

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产品目录号: A16126

库存状态:中国现货中国现货

产品名 目录号 价格 数量
LY3023414 5mg A16126-5
¥ 1,000.00
LY3023414 10mg A16126-10
¥ 1,800.00
LY3023414 50mg A16126-50
¥ 7,600.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

LY3023414 is an oral ATP competitive inhibitor of the class I PI3K isoforms, mTOR and DNA-PK, extracted from patent WO/2012097039A1, compound example 1, has an IC50 of 64.9 nM, 42.1 nM, 10.6 nM, 19.1 nM for Akt1(pT308), Akt1 (pS473), P70S6(pT389), S6RP(pS240/242).

LY3023414

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顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 LY3023414 发表的文献 (1)
  • Zou Y, .et al. Targeting PI3K-AKT-mTOR by LY3023414 inhibits human skin squamous cell carcinoma cell growth in vitro and in vivo, Biochem Biophys Res Commun, 2017, Aug 19;490(2):385-392 PMID: 28623128

Chemical Information

目录号 A16126
Mechanism of action Inhibitor
分子量 406.49
化学分子式 C23H26N4O3
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 1386874-06-1
Synonyms LY-3023414, LY 3023414
SMILES code CC(CN1C2=C3C=C(C=CC3=NC=C2N(C1=O)C)C4=CC(=CN=C4)C(C)(C)O)OC
化学名称 8-[5-(2-hydroxypropan-2-yl)pyridin-3-yl]-1-[(2S)-2-methoxypropyl]-3-methylimidazo[4,5-c]quinolin-2-one

生物活性

Description
LY3023414 is an oral ATP competitive inhibitor of the class I PI3K isoforms, mTOR and DNA-PK, extracted from patent WO/2012097039A1, compound example 1, has an IC50 of 64.9 nM, 42.1 nM, 10.6 nM, 19.1 nM for Akt1(pT308), Akt1 (pS473), P70S6(pT389), S6RP(pS240/242).
Targets
class I PI3K isoforms mTOR kinase DNA-PK

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 24.6 mL 123 mL 246.01mL
0.5 mM 4.92 mL 24.6 mL 49.2 mL
1 mM 2.46 mL 12.3 mL 24.6 mL
5 mM 0.49 mL 2.46 mL 4.92 mL

*The above data is based on the productmolecular weight 406.49. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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