Crenigacestat (LY3039478)

Name: Crenigacestat (LY3039478)
SKU: A13544
Price: 350 CNY
Rating: 5 (288 reviews)

目录号: A13544

Notch 抑制剂

LY3039478 是一种口服生物利用度高的新型小分子 Notch 抑制剂，在测试的大多数肿瘤细胞系中，其 IC50 约为 1nM。

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Grouped product items
规格	价格	库存
1mg	¥350.00	现货
5mg	¥805.00	现货
10mg	¥1,330.00	现货
25mg	¥2,555.00	现货
50mg	¥4,830.00	现货
100mg	¥8,960.00	现货
*10mM 1mL in DMSO**	¥805.00	现货
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Data Sheet

SDS

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生物活性

Discription

LY3039478 is a orally bioavailable, novel small molecule Notch inhibitor with an IC50 of ~1nM in most of the tumor cell lines tested.

Cell Research

Cell Line	Type	Value	Description	References

产品信息

目录号	A13544
分子式	C22H23F3N4O4
分子量	464.43763
CAS号	1421438-81-4
SMILES	C[C@@H](C(=O)N[C@H]1C2=CC=CC=C2C3=C(N=CC=C3)N(C1=O)CCO)NC(=O)CCC(F)(F)F
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro	DMSO	81 mg/mL (174.4 mM)
	Water	Insoluble
	Ethanol	62 mg/mL (133.49 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	21.53 mL	107.66 mL	215.31 mL
0.5 mM	4.31 mL	21.53 mL	43.06 mL
1 mM	2.15 mL	10.77 mL	21.53 mL
5 mM	0.43 mL	2.15 mL	4.31 mL

Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

Calculate Reset

* Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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