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LY315920 (Varespladib)

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HnsPLA 抑制剂

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产品目录号: A10548

库存状态:中国现货中国现货

产品名 目录号 价格 数量
LY315920 5mg A10548-5
¥ 600.00
LY315920 10mg A10548-10
¥ 1,100.00
LY315920 50mg A10548-50
¥ 3,300.00
LY315920 100mg A10548-100
¥ 5,500.00
LY315920 (Varespladib) 10mM * 1mL in DMSO A10548-10mM-D
¥ 600.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

LY315920 (Varespladib) is an inhibitor of the IIa, V, and X isoforms of secretory phospholipase A2 (sPLA2).

LY315920 (Varespladib)

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顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 LY315920 (Varespladib) 发表的文献 (2)
  • Yap WH, .et al. Differential effects of sPLA2-GV and GX on cellular proliferation and lipid accumulation in HT29 colon cancer cells, Mol Cell Biochem, 2018, Oct;447(1-2):93-101 PMID: 29374817
  • Yamato Okita, .et al. Interleukin-22-Induced Antimicrobial Phospholipase A2 Group IIA Mediates Protective Innate Immunity of Nonhematopoietic Cells against Listeria monocytogenes, Infect Immun, 2016, Feb; 84(2): 573每579 PMID: 26644377

Chemical Information

目录号 A10548
Mechanism of action Inhibitor
分子量 380.4
化学分子式 C21H20N2O5
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 172732-68-2
Synonyms LY-315920, S-5920
SMILES code CCC1=C(C2=C(N1CC3=CC=CC=C3)C=CC=C2OCC(=O)O)C(=O)C(=O)N
化学名称 2-[2-ethyl-3-oxamoyl-1-(phenylmethyl)indol-4-yl]oxyacetic acid

生物活性

Description
LY315920 (Varespladib) is an inhibitor of the IIa, V, and X isoforms of secretory phospholipase A2 (sPLA2).
Targets
hnsPLA2
7 nM

溶解性

Solubility (25°C) * In vitro DMSO 76 mg/mL (199.79 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 26.29 mL 131.44 mL 262.88mL
0.5 mM 5.26 mL 26.29 mL 52.58 mL
1 mM 2.63 mL 13.14 mL 26.29 mL
5 mM 0.53 mL 2.63 mL 5.26 mL

*The above data is based on the productmolecular weight 380.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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