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TGF??R-I 抑制剂

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产品目录号: A13446


产品名 目录号 价格 数量
LY364947 10mg A13446-10
¥ 600.00
LY364947 25mg A13446-25
¥ 1,200.00
LY364947 50mg A13446-50
¥ 2,000.00



LY364947 is a diheteroaryl-substituted pyrazole compound used as a selective, ATP-competitive inhibitor of TGF-βRI (TGF-β Receptor I kinase).





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Chemical Information

目录号 A13446
Mechanism of action Inhibitor
分子量 272.3
化学分子式 C17H12N4
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 396129-53-6
Synonyms HTS 466284 ,TGF-β RI Kinase Inhibitor
SMILES code C1=CC=C2C(=C1)C(=CC=N2)C3=C(NN=C3)C4=CC=CC=N4
化学名称 4-[3-(2-pyridinyl)-1H-pyrazol-4-yl]-quinoline


LY364947 is a diheteroaryl-substituted pyrazole compound used as a selective, ATP-competitive inhibitor of TGF-βRI (TGF-β Receptor I kinase).
TGFβRI (Cell-free assay) RIPK2 (Cell-free assay) CK1δ (Cell-free assay) TGFβRII (Cell-free assay) MLK-7K (Cell-free assay)
59 nM0.11 μM0.22 μM0.4 μM1.4 μM


Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 36.72 mL 183.62 mL 367.24mL
0.5 mM 7.34 mL 36.72 mL 73.45 mL
1 mM 3.67 mL 18.36 mL 36.72 mL
5 mM 0.73 mL 3.67 mL 7.34 mL

*The above data is based on the productmolecular weight 272.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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