M6903 is a humanized monoclonal IgG2 antibody that specifically targets T cell immunoglobulin and mucin domain-3 (TIM-3), exhibiting a dissociation constant (K_D) of 2.3 nM for human TIM-3. This antibody effectively binds to TIM-3, inhibiting its interaction with key ligands including phosphatidylserine (PtdSer), carcinoembryonic antigen cell adhesion-related molecule 1 (CEACAM1), and galectin 9 (Gal-9). By blocking these interactions, M6903 mitigates TIM-3-mediated suppression of T cell activity, thereby activating antigen-specific T cells and enhancing anti-tumor immune responses. This antibody is particularly valuable for research focused on cancer immunology and the development of immunotherapeutic strategies.
M6903 is a humanized monoclonal IgG2 antibody that specifically targets T cell immunoglobulin and mucin domain-3 (TIM-3), exhibiting a dissociation constant (K_D) of 2.3 nM for human TIM-3. This antibody effectively binds to TIM-3, inhibiting its interaction with key ligands including phosphatidylserine (PtdSer), carcinoembryonic antigen cell adhesion-related molecule 1 (CEACAM1), and galectin 9 (Gal-9). By blocking these interactions, M6903 mitigates TIM-3-mediated suppression of T cell activity, thereby activating antigen-specific T cells and enhancing anti-tumor immune responses. This antibody is particularly valuable for research focused on cancer immunology and the development of immunotherapeutic strategies.
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