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- S Ishikawa, .et al. Statins inhibit tumor progression via an enhancer of zeste homolog 2-mediated epigenetic alteration in colorectal cancer, Int J Cancer., 2014, 135(11): 2528每2536 PMID: 24346863
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|Mechanism of action||Inhibitor|
|储存方式||at -20°C 2 years|
|MC1568 is a member of HDAC inhibitors that inhibits the histone deacetylase class II by modifying the genetic expression of various important genes of cell cycle mostly at G1 phase, resulting in the death of breast cancer cells by apoptosis.|
|Solubility (25°C) *||In vitro||DMSO||13 mg/mL (41.36 mM)|
|Water||<1 mg/mL (<1 mM)|
|Ethanol||<1 mg/mL (<1 mM)|
|In vivo||0.5% CMC||5 mg/mL|
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.1 mM||31.82 mL||159.08 mL||318.17mL|
|0.5 mM||6.36 mL||31.82 mL||63.63 mL|
|1 mM||3.18 mL||15.91 mL||31.82 mL|
|5 mM||0.64 mL||3.18 mL||6.36 mL|
*The above data is based on the productmolecular weight 314.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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