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MC1568

促销

HDAC 抑制剂

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产品目录号: A10560

库存状态:中国现货中国现货

产品名 目录号 价格 数量
MC1568 10mg A10560-10
¥ 500.00
MC1568 25mg A10560-25
¥ 900.00
MC1568 50mg A10560-50
¥ 1,500.00
MC1568 100mg A10560-100
¥ 2,800.00
MC1568 10mM * 1mL in DMSO A10560-10mM-D
¥ 500.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

MC1568 is a member of HDAC inhibitors that inhibits the histone deacetylase class II by modifying the genetic expression of various important genes of cell cycle mostly at G1 phase, resulting in the death of breast cancer cells by apoptosis.

MC1568

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顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 MC1568 发表的文献 (3)
  • Minoru Ueda, .et al. The Distinct Roles of Class I and II RPD3-Like Histone Deacetylases in Salinity Stress Response, Plant Physiol, 2017, Dec; 175(4): 1760每1773 PMID: 29018096
  • S Ishikawa, .et al. Statins inhibit tumor progression via an enhancer of zeste homolog 2-mediated epigenetic alteration in colorectal cancer, Int J Cancer., 2014, 135(11): 2528每2536 PMID: 24346863
  • Usui T, .et al. Histone deacetylase 4 controls neointimal hyperplasia via stimulating proliferation and migration of vascular smooth muscle cells., Hypertension., 2014, Feb;63(2):397-403 PMID: 24166750

Chemical Information

目录号 A10560
Mechanism of action Inhibitor
分子量 314.3
化学分子式 C17H15FN2O3
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 852475-26-4
Synonyms MC-1568
SMILES code CN1C=C(C=C1/C=C/C(=O)NO)/C=C/C(=O)C2=CC(=CC=C2)F
化学名称 3-[5-(3-(3-Fluorophenyl)-3-oxopropen-1-yl)-1-methyl-1H-pyrrol-2-yl]-N-hydroxy-2-propenamide

生物活性

Description
MC1568 is a member of HDAC inhibitors that inhibits the histone deacetylase class II by modifying the genetic expression of various important genes of cell cycle mostly at G1 phase, resulting in the death of breast cancer cells by apoptosis.
Targets
HD1-A (Maize) (Cell-free assay) HD1-B (Maize) (Cell-free assay)
100 nM3.4 μM

溶解性

Solubility (25°C) * In vitro DMSO 13 mg/mL (41.36 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 0.5% CMC 5 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 31.82 mL 159.08 mL 318.17mL
0.5 mM 6.36 mL 31.82 mL 63.63 mL
1 mM 3.18 mL 15.91 mL 31.82 mL
5 mM 0.64 mL 3.18 mL 6.36 mL

*The above data is based on the productmolecular weight 314.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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