MD-224

目录号: A18712

MDM2 degrader

MD-224

MD-224 Chemical Structure

CAS NO. 2136247-12-4

MD-224 is a first-in-class and highly potent small-molecule human murine double minute 2 (MDM2) degrader based on the proteolysistargeting chimera (PROTAC) concept. MD-224 has the potential to be a new class of anticancer agent.

库存: 现货

规格 价格 数量
5 mg
¥ 1,260.00
10 mg
¥ 2,240.00
50 mg
¥ 6,160.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

产品详情

MD-224 is a first-in-class and highly potent small-molecule human murine double minute 2 (MDM2) degrader based on the proteolysistargeting chimera (PROTAC) concept. MD-224 has the potential to be a new class of anticancer agent.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 11.24 mL 56.19 mL 112.38 mL
0.5 mM 2.25 mL 11.24 mL 22.48 mL
1 mM 1.12 mL 5.62 mL 11.24 mL
5 mM 0.22 mL 1.12 mL 2.25 mL

*The above data is based on the productmolecular weight 889.8. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A18712
作用机制 Degrader (降解剂)
M. Wt 889.8
Formula C48H43Cl2FN6O6
Purity >99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No. 2136247-12-4
Synonyms MD224, MD 224
SMILES FC1=C(Cl)C=CC=C1[C@@H]2[C@@]3(C(C=CC(Cl)=C4)=C4NC3=O)C5(CCCCC5)N[C@H]2C(NC6=CC=C(C(NCCCC#CC7=C(CN(C8C(NC(CC8)=O)=O)C9=O)C9=CC=C7)=O)C=C6)=O

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