MD2-TLR4-IN-1

Name: MD2-TLR4-IN-1
SKU: A18452
Price: 350 CNY
Rating: 5 (288 reviews)

目录号: A18452

MD2-TLR4 抑制剂

MD2-TLR4-IN-1（化合物22m）是一种髓样分化蛋白2/类饱和受体4（MD2-TLR4）复合体的抑制剂，能够抑制脂多糖（LPS）诱导的巨噬细胞中肿瘤坏死因子α（TNF-α）和白细胞介素-6（IL-6）的表达，其半抑制浓度（IC50）分别为0.89 μM和0.53 μM。

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Grouped product items
规格	价格	库存
1mg	¥350.00	现货
5mg	¥910.00	现货
10mg	¥1,505.00	现货
25mg	¥2,625.00	现货
50mg	¥3,710.00	现货
100mg	¥4,900.00	现货
200mg	¥6,615.00	现货
*10mM 1mL in DMSO**	¥1,015.00	现货
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Data Sheet

SDS

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生物活性

Discription	MD2-TLR4-IN-1 (compound 22m) is an inhibitor of myeloid differentiation protein 2/toll-like receptor 4 (MD2-TLR4) complex, inhibiting lipopolysaccharides (LPS)-induced expression of tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6) in macrophages with IC50 values of 0.89 μM and 0.53 μM, respectively.

产品信息

目录号	A18452
分子式	C22H14Cl2N4O
分子量	421.28
CAS号	2249801-12-3
SMILES	ClC1=C(C(NC2=CC(C(C3=CC=C(NC=C4)C4=C3)=NN5)=C5C=C2)=O)C(Cl)=CC=C1
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro	DMSO	81 mg/mL (192.27 mM)
	Water	Insoluble
	Ethanol	5 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	23.74 mL	118.69 mL	237.37 mL
0.5 mM	4.75 mL	23.74 mL	47.47 mL
1 mM	2.37 mL	11.87 mL	23.74 mL
5 mM	0.47 mL	2.37 mL	4.75 mL

Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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* Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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