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MDK-8582, also known as Hnps-PLA Inhibitor, is an inhibitor of human nonpancreatic secretory Phospholipase A (hnps-PLA). The best one inhibited hnps-PLA(2) and LTA(4)H-h with IC(50) values of 9.2 ± 0.5 μM and 2.4 ± 1.4 μM, respectively.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 26.36 mL | 131.78 mL | 263.56 mL |
| 0.5 mM | 5.27 mL | 26.36 mL | 52.71 mL |
| 1 mM | 2.64 mL | 13.18 mL | 26.36 mL |
| 5 mM | 0.53 mL | 2.64 mL | 5.27 mL |
*The above data is based on the productmolecular weight 379.42. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A22644 |
|---|---|
| M. Wt | 379.42 |
| Formula | C21H21N3O4 |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 2 years |
| CAS No. | 185298-58-2 |
| Synonyms | MDK8582,MDK 8582 |
| SMILES | O=C(N)C(C1=C(CC)N(CC2=CC=CC=C2)C3=C1C(OCC(N)=O)=CC=C3)=O |
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