Mecbotamab is a humanized IgG1-?? monoclonal antibody specifically designed to target the AXL receptor tyrosine kinase (AXL). This antibody functions as a conditionally active biologic (CAB), allowing for site-specific activation. Mecbotamab can be conjugated to the cytotoxic agent monomethyl auristatin E (MMAE) through a cleavable linker, creating the antibody-drug conjugate (ADC) known as Mecbotamab vedotin (BA3011). This conjugation enhances its potential for targeted cancer therapy by enabling the selective delivery of the cytotoxic drug to AXL-expressing tumor cells, thereby minimizing systemic toxicity.
Mecbotamab is a humanized IgG1-?? monoclonal antibody specifically designed to target the AXL receptor tyrosine kinase (AXL). This antibody functions as a conditionally active biologic (CAB), allowing for site-specific activation. Mecbotamab can be conjugated to the cytotoxic agent monomethyl auristatin E (MMAE) through a cleavable linker, creating the antibody-drug conjugate (ADC) known as Mecbotamab vedotin (BA3011). This conjugation enhances its potential for targeted cancer therapy by enabling the selective delivery of the cytotoxic drug to AXL-expressing tumor cells, thereby minimizing systemic toxicity.
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