MEK162 (ARRY-438162, Binimetinib)

Name: MEK162 (ARRY-438162, Binimetinib)
SKU: A11493
Price: 210 CNY
Rating: 5 (3 reviews)

目录号: A11493

MEK1/2 抑制剂

3 篇发表文献

MEK162 (ARRY-438162) 是一种强效、选择性的、非竞争性 ATP 抑制剂，针对 MEK1/2。

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Grouped product items
规格	价格	库存
5mg	¥210.00	现货
10mg	¥350.00	现货
25mg	¥420.00	现货
50mg	¥525.00	现货
100mg	¥630.00	现货
200mg	¥1,050.00	现货
*10mM 1mL in DMSO**	¥315.00	现货
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重要通知：仅供研究使用。我们不向患者销售。

Data Sheet

SDS

顾客使用 Adooq 产品发表的高质量科研文献

Adooq用户使用MEK162 (ARRY-438162, Binimetinib)发表的3篇文献

S Shahab, .et al. , J Neuropathol Exp Neurol, 2020, Jul 1;79(7):746-753

Seidel D, .et al. , Biosens Bioelectron, 2019, Jan 1;123:185-194 PMID: 30201332

Alquezar C, .et al. , Eur Neuropsychopharmacol, 2015, Mar;25(3):386-403 PMID: 25624003

生物活性

Discription

MEK162 (ARRY-438162) is a potent, selective, ATP uncompetitive inhibitor of MEK1/2.

Targets

Target	Value

产品信息

目录号	A11493
分子式	C17H15BrF2N4O3
分子量	440
CAS号	606143-89-9
SMILES	CN1C=NC2=C1C=C(C(=C2F)NC3=C(C=C(C=C3)Br)F)C(=O)NOCCO
其他名称	ARRY-162, MEK-162, MEK 162
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro (25°C)	DMSO	Warmed: 86 mg/mL (194.91 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	1% CMC+0.5% Tween-80	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	22.73 mL	113.64 mL	227.27 mL
0.5 mM	4.55 mL	22.73 mL	45.45 mL
1 mM	2.27 mL	11.36 mL	22.73 mL
5 mM	0.45 mL	2.27 mL	4.55 mL

Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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* Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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