MEK162 (ARRY-438162, Binimetinib)

目录号: A11493

MEK1/2 inhibitor

MEK162 (ARRY-438162, Binimetinib)

MEK162 (ARRY-438162, Binimetinib) Chemical Structure

CAS NO. 606143-89-9

MEK162 (ARRY-438162) is a potent, selective, ATP uncompetitive inhibitor of MEK1/2.

库存: 现货

规格 价格 数量
5 mg
¥ 400.00
10 mg
¥ 600.00
25 mg
¥ 1,000.00
50 mg
¥ 1,400.00
10mM * 1mL in DMSO
¥ 650.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

详情

MEK162 (ARRY-438162) is a potent, selective, ATP uncompetitive inhibitor of MEK1/2.
Targets
MEK
12 nM
In vitro (25°C) DMSO 88 mg/mL (199.44 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 1% CMC/0.5% Tween-80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.73 mL 113.64 mL 227.27 mL
0.5 mM 4.55 mL 22.73 mL 45.45 mL
1 mM 2.27 mL 11.36 mL 22.73 mL
5 mM 0.45 mL 2.27 mL 4.55 mL

*The above data is based on the productmolecular weight 440.0 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Technical Details

目录号 A11493
MECHANISM OF ACTION Inhibitor
M. Wt 440.0
Formula C17H15BrF2N4O3
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 606143-89-9
Synonyms ARRY-162, MEK-162, MEK 162
SMILES CN1C=NC2=C1C=C(C(=C2F)NC3=C(C=C(C=C3)Br)F)C(=O)NOCCO

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