Merafloxacin

Name: Merafloxacin
SKU: A22483
Price: 350 CNY
Rating: 5 (288 reviews)

目录号: A22483

Merafloxacin，也被称为 CI 934，是一种氟喹诺酮类抗菌药物，同时也被确认为 SARS-CoV-2 的 -1 PRF 抑制剂。Merafloxacin 对 pseudoknot 区域内的突变具有强大的抗性，并且对其他 beta 冠状病毒的 -1 PRF 同样有效。重要的是，merafloxacin 对 -1 PRF 的抑制显著阻碍了 SARS-CoV-2 在 Vero E6 细胞中的复制，从而为针对 -1 PRF 作为 SARS-CoV-2 的有效抗病毒策略提供了原理验证。

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Grouped product items
规格	价格	库存
1mg	¥350.00	现货
2mg	¥490.00	现货
5mg	¥805.00	现货
10mg	¥1,330.00	现货
25mg	¥2,485.00	现货
50mg	¥3,710.00	现货
100mg	¥5,390.00	现货
*10mM 1mL in DMSO**	¥875.00	现货
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SDS

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生物活性

Discription

Merafloxacin, also known as CI 934, is a fluoroquinolone antibacterial, which was also identified as a -1 PRF inhibitor of SARS-CoV-2. Frameshift inhibition by merafloxacin is robust to mutations within the pseudoknot region and is similarly effective on -1 PRF of other beta coronaviruses. Importantly, frameshift inhibition by merafloxacin substantially impedes SARS-CoV-2 replication in Vero E6 cells, thereby providing the proof of principle of targeting -1 PRF as an effective antiviral strategy for SARS-CoV-2.

Cell Research

Cell Line	Type	Value	Description	References

产品信息

目录号	A22483
分子式	C19H23F2N3O
分子量	379.4078
CAS号	91188-00-0
SMILES	O=C(C1=CN(CC)C2=C(C=C(F)C(N3CC(CNCC)CC3)=C2F)C1=O)O
其他名称	CI 934, CI-934, CI934, Merafloxacin,
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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