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Methotrexate (Amethopterin) disodium, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis. Methotrexate disodium, also an immunosuppressant and antineoplastic agent, is used for the research of rheumatoid arthritis and a number of different cancers (such as acute lymphoblastic leukemia).
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 20.06 mL | 100.32 mL | 200.64 mL |
| 0.5 mM | 4.01 mL | 20.06 mL | 40.13 mL |
| 1 mM | 2.01 mL | 10.03 mL | 20.06 mL |
| 5 mM | 0.4 mL | 2.01 mL | 4.01 mL |
*The above data is based on the productmolecular weight 498.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A17943 |
|---|---|
| M. Wt | 498.4 |
| Formula | C20H20N8Na2O5 |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 2 years |
| CAS No. | 7413-34-5 |
| Synonyms | Amethopterin disodium; CL14377 disodium; WR19039 disodium |
| SMILES | NC1=NC(N)=C2C(N=CC(CN(C)C3=CC=C(C(N[C@@H](CCC(O[Na])=O)C(O[Na])=O)=O)C=C3)=N2)=N1 |
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