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Proteasome 抑制剂

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产品目录号: A11043


产品名 目录号 价格 数量
MG-132 10mg A11043-10
¥ 500.00
MG-132 25mg A11043-25
¥ 1,200.00
MG-132 50mg A11043-50
¥ 2,000.00
MG-132 100mg A11043-100
¥ 3,200.00
MG-132 10mM * 1mL in DMSO A11043-10mM-D
¥ 650.00



MG-132 is a potent cell-permeable inhibitor of proteasome (IC50 = 100 nM) and calpain (IC50 = 1.2 μM).





顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 MG-132 发表的文献 (3)
  • Paudel DB, .et al. Expression and antiviral function of ARGONAUTE 2 in Nicotiana benthamiana plants infected with two isolates of tomato ringspot virus with varying degrees of virulence, Virology, 2018, Nov;524:127-139 PMID: 30195250
  • Ohkusu-Tsukada K, .et al. The Role of Proteasome Inhibitor MG132 in 2,4-Dinitrofluorobenzene-Induced Atopic Dermatitis in NC/Nga Mice, Int Arch Allergy Immunol, 2018, 176(2):91-100 PMID: 29669333
  • Chi-Hung R. Or, .et al. Obatoclax, a Pan-BCL-2 Inhibitor, Targets Cyclin D1 for Degradation to Induce Antiproliferation in Human Colorectal Carcinoma Cells, Int J Mol Sci, 2016, Jan; 18(1): 44 PMID: 28035994

Chemical Information

目录号 A11043
Mechanism of action Inhibitor
分子量 475.6
化学分子式 C26H41N3O5
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 133407-82-6
Synonyms Z-Leu-Leu-Leu-CHO, Z-LLL-CHO, MG132
SMILES code CC(C)C[C@@H](C=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)OCC1=CC=CC=C1
化学名称 N-[(Phenylmethoxy)carbonyl]-L-leucyl-N-[(1S)-1-formyl-3-methylbutyl]-L-leucinamide


MG-132 is a potent cell-permeable inhibitor of proteasome (IC50 = 100 nM) and calpain (IC50 = 1.2 μM).
Proteasome (Cell-free assay)
100 nM


Solubility (25°C) * In vitro DMSO 95 mg/mL (199.73 mM)
Water <1 mg/mL (<1 mM)
Ethanol 95 mg/mL (199.73 mM)
In vivo 1% DMSO/30% polyethylene glycol/1% Tween 80, pH 4 6 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.


Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.03 mL 105.13 mL 210.26mL
0.5 mM 4.21 mL 21.03 mL 42.05 mL
1 mM 2.1 mL 10.51 mL 21.03 mL
5 mM 0.42 mL 2.1 mL 4.21 mL

*The above data is based on the productmolecular weight 475.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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