MG-132

Name: MG-132
SKU: A11043

目录号: A11043

Proteasome 抑制剂

Product Citations (11)

Vo Thi Anh Nguyet, .et al. Acquired resistance to severe ethanol stress-induced inhibition of proteasomal proteolysis in Saccharomyces cerevisiae, Biochim Biophys Acta Gen Subj, 2022, Sep 6;1866(12):130241 PMID: 36075516
Jalila Chagraoui, .et al. UM171 Preserves Epigenetic Marks that Are Reduced in Ex Vivo Culture of Human HSCs via Potentiation of the CLR3-KBTBD4 Complex, Cell Stem Cell, 2021, Jan 7;28(1):48-62.e6 PMID: 33417871
Eunsu Yoo, .et al. Anti-proliferative activity of A. Oxyphylla and its bioactive constituent nootkatone in colorectal cancer cells, BMC Cancer, 2020, Sep 14;20(1):881 PMID: 32928152
Hua Xu, .et al. Preclinical Study Using ABT263 to Increase Enzalutamide Sensitivity to Suppress Prostate Cancer Progression Via Targeting BCL2/ROS/USP26 Axis Through Altering ARv7 Protein Degradation, Cancers (Basel), 2020, Apr; 12(4): 831 PMID: 32235588
Chi-Hung R Or, .et al. Obatoclax, a Pan-BCL-2 Inhibitor, Downregulates Survivin to Induce Apoptosis in Human Colorectal Carcinoma Cells Via Suppressing WNT/β-catenin Signaling, Int J Mol Sci, 2020, Mar 5;21(5):1773 PMID: 32150830
Ghosh S, .et al. Interactions between Viperin, Vesicle-Associated Membrane Protein A, and Hepatitis C Virus Protein NS5A Modulate Viperin Activity and NS5A Degradation, Biochemistry, 2020, Feb 18;59(6):780-789 PMID: 31977203
Kondo H, .et al. PITHD1 is a proteasome-interacting protein essential for male fertilization, J Biol Chem, 2020, Feb 7;295(6):1658-1672 PMID: 31915251
Ohigashi I, .et al. Trans-omics Impact of Thymoproteasome in Cortical Thymic Epithelial Cells, Cell Rep, 2019, Nov 26;29(9):2901-2916 PMID: 31775054
Paudel DB, .et al. Expression and antiviral function of ARGONAUTE 2 in Nicotiana benthamiana plants infected with two isolates of tomato ringspot virus with varying degrees of virulence, Virology, 2018, Nov;524:127-139 PMID: 30195250
Ohkusu-Tsukada K, .et al. The Role of Proteasome Inhibitor MG132 in 2,4-Dinitrofluorobenzene-Induced Atopic Dermatitis in NC/Nga Mice, Int Arch Allergy Immunol, 2018, 176(2):91-100 PMID: 29669333
Chi-Hung R. Or, .et al. Obatoclax, a Pan-BCL-2 Inhibitor, Targets Cyclin D1 for Degradation to Induce Antiproliferation in Human Colorectal Carcinoma Cells, Int J Mol Sci, 2016, Jan; 18(1): 44 PMID: 28035994

MG-132 Chemical Structure

CAS NO. 133407-82-6

MG-132是蛋白酶体（IC50 = 100 nM）和钙蛋白酶（IC50 = 1.2μM）的有效的细胞渗透抑制剂。

库存：现货

规格	价格	数量
10 mg	￥ 500.00
25 mg	￥ 1,200.00
50 mg	￥ 2,000.00
100 mg	￥ 2,700.00
10mM * 1mL in DMSO	￥ 650.00

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产品仅用于科学研究，不针对患者销售，望谅解.

产品详情

生物活性

MG-132是蛋白酶体（IC50 = 100 nM）和钙蛋白酶（IC50 = 1.2μM）的有效的细胞渗透抑制剂。

靶点信息

Proteasome (Cell-free assay)
100 nM

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	21.03 mL	105.13 mL	210.26 mL
0.5 mM	4.21 mL	21.03 mL	42.05 mL
1 mM	2.1 mL	10.51 mL	21.03 mL
5 mM	0.42 mL	2.1 mL	4.21 mL

*The above data is based on the productmolecular weight 475.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A11043
作用机制	Inhibitor (抑制剂)
M. Wt	475.6
Formula	C26H41N3O5
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	133407-82-6
Synonyms	Z-Leu-Leu-Leu-CHO, Z-LLL-CHO, MG132
SMILES	CC(C)C[C@@H](C=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)OCC1=CC=CC=C1