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MGCD0103 (Mocetinostat)

HDAC 抑制剂

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产品目录号: A10586

库存状态:中国现货中国现货

产品名 目录号 价格 数量
MGCD0103 5mg A10586-5
¥ 400.00
MGCD0103 10mg A10586-10
¥ 500.00
MGCD0103 25mg A10586-25
¥ 700.00
MGCD0103 50mg A10586-50
¥ 990.00
MGCD0103 (Mocetinostat) 10mM * 1mL in DMSO A10586-10mM-D
¥ 550.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

MGCD0103 (Mocetinostat) is a benzamide histone deacetylase inhibitor by inhibiting mainly histone deacetylase 1 (HDAC1), but also HDAC2, HDAC3, and HDAC11.

MGCD0103 (Mocetinostat)

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顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 MGCD0103 (Mocetinostat) 发表的文献 (2)
  • Mari Ishigami-Yuasa, .et al. Class IIb HDAC Inhibition Enhances the Inhibitory Effect of Am80, a Synthetic Retinoid, in Prostate Cancer, Biol Pharm Bull, 2019, 42, 448每452
  • Guang Bai, .et al. Chapter 1 - Epigenetic Tools in Chronic Pain Studies, Epigenetics of Chronic Pain, 2019, Pages 1-48

Chemical Information

目录号 A10586
Mechanism of action Inhibitor
分子量 396.4
化学分子式 C23H20N6O
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 726169-73-9
Synonyms MGCD-0103
SMILES code C1=CC=C(C(=C1)N)NC(=O)C2=CC=C(C=C2)CNC3=NC=CC(=N3)C4=CN=CC=C4
化学名称 N-(2-Aminophenyl)-4-[[(4-pyridin-3-ylpyrimidin-2-yl)amino]methyl] benzamide

生物活性

Description
MGCD0103 (Mocetinostat) is a benzamide histone deacetylase inhibitor by inhibiting mainly histone deacetylase 1 (HDAC1), but also HDAC2, HDAC3, and HDAC11.
Targets
Target Value
HDAC1IC50: 0.15μM
HDAC2IC50: 0.29μM
HDAC11IC50: 0.59μM
HDAC3IC50: 1.66μM
HDAC4IC50: >10μM
HDAC5IC50: >10μM
HDAC6IC50: >10μM
HDAC7IC50: >10μM
HDAC8IC50: >10μM

溶解性

Solubility (25°C) * In vitro DMSO 13 mg/mL (32.79 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 25.23 mL 126.14 mL 252.27mL
0.5 mM 5.05 mL 25.23 mL 50.45 mL
1 mM 2.52 mL 12.61 mL 25.23 mL
5 mM 0.5 mL 2.52 mL 5.05 mL

*The above data is based on the productmolecular weight 396.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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