产品详情

生物活性

MI 2直接与MALT1结合并在体外和体内抑制活化的B细胞样弥漫性大B细胞淋巴瘤（ABC-DLBCL）。

靶点信息

MALT1
5.84 μM

溶解度 *

In vitro (25°C)	DMSO	77 mg/mL (168.96 mM)
	Water	Insoluble
	Ethanol	77 mg/mL (168.96 mM)
In vivo	5%DMSO+30%PEG300+5%Tween-80+ddH2O	4 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	21.94 mL	109.72 mL	219.43 mL
0.5 mM	4.39 mL	21.94 mL	43.89 mL
1 mM	2.19 mL	10.97 mL	21.94 mL
5 mM	0.44 mL	2.19 mL	4.39 mL

*The above data is based on the productmolecular weight 455.72. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A12928
作用机制	Inhibitor (抑制剂)
M. Wt	455.72
Formula	C19H17Cl3N4O3
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	1047953-91-2
Synonyms	MALT1 inhibitor, MI-2
SMILES	COCCOC1=NN(C(=N1)C2=CC(=C(C=C2)Cl)Cl)C3=CC=C(C=C3)NC(=O)CCl