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MIK665

产品详情

生物活性

MIK665 (S-64315) is a special Mcl-1 inhibitor extracted from patent WO2016207225A1, compound Preparation 13, has an IC50 of 1.81 nM.

溶解度 *

In vitro	DMSO	92 mg/mL (105.09 mM)
	Water	Insoluble
	Ethanol	<1 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	11.42 mL	57.12 mL	114.23 mL
0.5 mM	2.28 mL	11.42 mL	22.85 mL
1 mM	1.14 mL	5.71 mL	11.42 mL
5 mM	0.23 mL	1.14 mL	2.28 mL

*The above data is based on the productmolecular weight 875.41. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A18362
作用机制	Inhibitor (抑制剂)
M. Wt	875.41
Formula	C47H44ClFN6O6S
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	1799631-75-6
Synonyms	MIK665; MIK-665; MIK 665; S 64315; S-64315; S64315
SMILES	OC([C@@H](CC(C=CC=C1)=C1OCC2=CC=NC(C3=CC=CC=C3OC)=N2)OC4=C5[C@]([C@]6=C(C)C(Cl)=C(OCCN7CCN(C)CC7)C=C6)=C(C8=CC=C(F)C=C8)SC5=NC=N4)=O