Milatuzumab (hLL1; MEDI-115) is a humanized monoclonal antibody targeting CD74, an integral membrane protein implicated in the promotion of B-cell growth and survival. This antibody induces the generation of reactive oxygen species and disrupts mitochondrial membrane potential, leading to apoptosis. Additionally, Milatuzumab reduces CD20/CD74 aggregates and cell adhesion, further promoting cell death. This antibody is pivotal for research into the mechanisms of B-cell malignancies and autoimmune diseases, where CD74 plays a key role.
Milatuzumab (hLL1; MEDI-115) is a humanized monoclonal antibody targeting CD74, an integral membrane protein implicated in the promotion of B-cell growth and survival. This antibody induces the generation of reactive oxygen species and disrupts mitochondrial membrane potential, leading to apoptosis. Additionally, Milatuzumab reduces CD20/CD74 aggregates and cell adhesion, further promoting cell death. This antibody is pivotal for research into the mechanisms of B-cell malignancies and autoimmune diseases, where CD74 plays a key role.
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