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MK-0674 is a potent, orally bioavailable and selective cathepsin K inhibitor, with an IC50 of 0.4 nM, shows 1156, 1465, 11857 and 243 fold selectivity over Cat B, Cat F, Cat L and Cat S.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 18.96 mL | 94.79 mL | 189.57 mL |
| 0.5 mM | 3.79 mL | 18.96 mL | 37.91 mL |
| 1 mM | 1.9 mL | 9.48 mL | 18.96 mL |
| 5 mM | 0.38 mL | 1.9 mL | 3.79 mL |
*The above data is based on the productmolecular weight 527.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A21558 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 527.5 |
| Formula | C26H27F6N3O2 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 887781-62-6 |
| Synonyms | MK0674, MK 0674 |
| SMILES | N#CC1(CC1)NC([C@H](CC(C)(C)F)N[C@@H](C2=CC=C(C3=CC=C(C=C3)[C@@H](O)C(F)F)C=C2)C(F)(F)F)=O |
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