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MK-0812

CCR2 拮抗剂

158 Customer Reviews
产品目录号: A11127

库存状态:中国现货中国现货

产品名 目录号 价格 数量
MK-0812 5mg A11127-5
¥ 1,950.00
MK-0812 10mg A11127-10
¥ 3,600.00
MK-0812 50mg A11127-50
¥ 15,000.00
MK-0812 100mg A11127-100
¥ 25,000.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

MK-0812 is a potent and selective CCR2 antagonist with low nM affinity for CCR2 on human monocytes and low nM in the chemotaxis assay. It has good PK profiles in preclinical species and demonstrated efficacy in animal models.

MK-0812

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顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 MK-0812 发表的文献 (1)
  • Murakami K, .et al. CC chemokine ligand 2 and CXC chemokine ligand 8 as neutrophil chemoattractant factors in canine idiopathic polyarthritis, Vet Immunol Immunopathol, 2016, Dec;182:52-58 PMID: 27863550

Chemical Information

目录号 A11127
Mechanism of action Antagonist
分子量 469.5
化学分子式 C24H34F3N3O3
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 624733-88-6
Synonyms MK0812
SMILES code CC(C)[C@@]1(CC[C@H](C1)N[C@H]2CCOC[C@H]2OC)C(=O)N3CCC4=NC=C(C=C4C3)C(F)(F)F
化学名称 1,5-Anhydro-2,3-dideoxy-3-[[(1R,3S)-3-[[7,8-dihydro-3-(trifluoromethyl)-1,6-naphthyridin-6(5H)-yl]carbonyl]-3-(1-methylethyl)cyclopentyl]amino]-4-O-methyl-D-erythro-pentitol

生物活性

Description
MK-0812 is a potent and selective CCR2 antagonist with low nM affinity for CCR2 on human monocytes and low nM in the chemotaxis assay. It has good PK profiles in preclinical species and demonstrated efficacy in animal models.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.3 mL 106.5 mL 212.99mL
0.5 mM 4.26 mL 21.3 mL 42.6 mL
1 mM 2.13 mL 10.65 mL 21.3 mL
5 mM 0.43 mL 2.13 mL 4.26 mL

*The above data is based on the productmolecular weight 469.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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