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MK-1775是一种有效的体外和体内Wee1激酶抑制剂。
靶点信息
| Wee1 (Cell-free assay) | ||||
| 5.2 nM |
| In vitro (25°C) | DMSO | 71 mg/mL (141.82 mM) | |
| Water | Insoluble | ||
| Ethanol | 9 mg/mL (17.97 mM) | ||
| In vivo | 2% DMSO+30% PEG 300+5% Tween 80+ddH2O | 4 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 19.98 mL | 99.88 mL | 199.76 mL |
| 0.5 mM | 4 mL | 19.98 mL | 39.95 mL |
| 1 mM | 2 mL | 9.99 mL | 19.98 mL |
| 5 mM | 0.4 mL | 2 mL | 4 mL |
*The above data is based on the productmolecular weight 500.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A10599 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 500.6 |
| Formula | C27H32N8O2 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 955365-80-7 |
| Synonyms | MK1775,MK 1775, AZD-1775, AZD1775 |
| SMILES | CC(C)(C1=NC(=CC=C1)N2C3=NC(=NC=C3C(=O)N2CC=C)NC4=CC=C(C=C4)N5CCN(CC5)C)O |
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