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MK-1775

促销

WEE1 抑制剂

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产品目录号: A10599

库存状态:中国现货中国现货

产品名 目录号 价格 数量
MK-1775 5mg A10599-5
¥ 700.00
MK-1775 10mg A10599-10
¥ 900.00
MK-1775 25mg A10599-25
¥ 1,400.00
MK-1775 50mg A10599-50
¥ 2,500.00
MK-1775 10mM * 1mL in DMSO A10599-10mM-D
¥ 700.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

MK-1775 is a potent and selective Wee1 kinase inhibitor in vitro and in vivo.

MK-1775

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顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 MK-1775 发表的文献 (2)
  • 2018, .et al. Augmentation of the therapeutic efficacy of WEE1 kinase inhibitor AZD1775 by inhibiting the YAP每E2F1每DNA damage response pathway axis, FEBS Open Bio, 2018, Jun; 8(6): 1001每1012 PMID: 29928579
  • Rulina AV, .et al. Distinct outcomes of CRL-Nedd8 pathway inhibition reveal cancer cell plasticity, Cell Death Dis, 2016, Dec 1;7(12):e2505 PMID: 27906189

Chemical Information

目录号 A10599
Mechanism of action Inhibitor
分子量 500.6
化学分子式 C27H32N8O2
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 955365-80-7
Synonyms MK1775,MK 1775, AZD-1775, AZD 1775, AZD1775
SMILES code CC(C)(C1=NC(=CC=C1)N2C3=NC(=NC=C3C(=O)N2CC=C)NC4=CC=C(C=C4)N5CCN(CC5)C)O
化学名称 2-Allyl-1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)-6-(4-(4-methylpiperazin-1-yl)phenylamino)-1H-pyrazolo[3,4-d]pyrimidin-3(2H)-one

生物活性

Description
MK-1775 is a potent and selective Wee1 kinase inhibitor in vitro and in vivo.
Targets
Wee1 (Cell-free assay)
5.2 nM

溶解性

Solubility (25°C) * In vitro DMSO 80 mg/mL (159.8 mM)
Water 0.0001 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 0.5% methylcellulose 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.98 mL 99.88 mL 199.76mL
0.5 mM 4 mL 19.98 mL 39.95 mL
1 mM 2 mL 9.99 mL 19.98 mL
5 mM 0.4 mL 2 mL 4 mL

*The above data is based on the productmolecular weight 500.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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