MK-2461

目录号: A11753

c-Met Inhibitor

MK-2461 Chemical Structure

CAS NO. 917879-39-1

MK-2461, a novel multitargeted kinase inhibitor, preferentially inhibits the activated c-Met receptor.

库存: 现货

规格 价格 数量
5 mg
¥ 1,800.00
10 mg
¥ 3,200.00
25 mg
¥ 6,500.00
50 mg
¥ 11,500.00
10mM * 1mL in DMSO
¥ 2,370.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

详情

MK-2461, a novel multitargeted kinase inhibitor, preferentially inhibits the activated c-Met receptor.
Targets
Target Value
c-Met(M1250T)IC50: 0.4nM
c-Met(Y1235D)IC50: 0.5nM
c-Met(Y1230H)IC50: 1.0nM
c-Met(N1100)IC50: 1.5nM
c-Met(Y1230C)IC50: 1.5nM
c-MetIC50: 2.5nM
RONIC50: 7nM
FLT1IC50: 10nM
FLT3IC50: 22nM
PDGFRβIC50: 22nM
MerIC50: 24nM
FGFR2IC50: 39nM
KDRIC50: 44nM
TrkAIC50: 46nM
FGFR3IC50: 50nM
TrkBIC50: 61nM
FGFR1IC50: 65nM
FLT4IC50: 78nM
DRAK1IC50: 199nM
JAK2IC50: 225nM
IRAK4IC50: 298nM
MELKIC50: 606nM
RETIC50: 635nM
DYRK2IC50: 1.143μM
MLK1IC50: 4.303μM
IRAK1IC50: 5.459μM
AblIC50: 7.747μM
In vitro (25°C) DMSO 99 mg/mL (199.77 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 1% DMSO/30% polyethylene glycol/1% Tween 80, pH 4 15 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.18 mL 100.89 mL 201.78 mL
0.5 mM 4.04 mL 20.18 mL 40.36 mL
1 mM 2.02 mL 10.09 mL 20.18 mL
5 mM 0.4 mL 2.02 mL 4.04 mL

*The above data is based on the productmolecular weight 495.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A11753
MECHANISM OF ACTION Inhibitor
M. Wt 495.6
Formula C24H25N5O5S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 917879-39-1
Synonyms MK2461
SMILES CN1C=C(C=N1)C2=CN=C3C=CC4=C(C=C(C=C4)NS(=O)(=O)N(C)C[C@@H]5COCCO5)C(=O)C3=C2

产品标签

产品标签

使用空格分隔标签。使用单引号(')标注词组。

Product Questions

Product Questions

No Questions
您还可能对下列产品感兴趣
Keywords:购买 MK-2461 | MK-2461 供应商 | 订购 MK-2461 | MK-2461 价格 | MK-2461 生产商 | 订单 MK-2461 | MK-2461 代理商 | 购买 917879-39-1| 917879-39-1 供应商 | 订购 917879-39-1 | 917879-39-1 价格 | 917879-39-1 生产商 | 订单 917879-39-1 | 917879-39-1 代理商|buy MK-2461 | MK-2461 Supplier | purchase MK-2461 | MK-2461 cost | MK-2461 manufacturer | order MK-2461 | MK-2461 distributor | buy 917879-39-1| 917879-39-1 Supplier | purchase 917879-39-1 | 917879-39-1 cost | 917879-39-1 manufacturer | order 917879-39-1 | 917879-39-1 distributor
Rewards