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MK-2461

c-Met 抑制剂

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产品目录号: A11753

库存状态:中国现货中国现货

产品名 目录号 价格 数量
MK-2461 5mg A11753-5
¥ 1,800.00
MK-2461 10mg A11753-10
¥ 3,200.00
MK-2461 25mg A11753-25
¥ 6,500.00
MK-2461 50mg A11753-50
¥ 11,500.00
MK-2461 10mM * 1mL in DMSO A11753-10mM-D
¥ 2,370.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

MK-2461, a novel multitargeted kinase inhibitor, preferentially inhibits the activated c-Met receptor.

MK-2461

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Chemical Information

目录号 A11753
Mechanism of action Inhibitor
分子量 495.6
化学分子式 C24H25N5O5S
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 917879-39-1
Synonyms MK2461
SMILES code CN1C=C(C=N1)C2=CN=C3C=CC4=C(C=C(C=C4)NS(=O)(=O)N(C)C[C@@H]5COCCO5)C(=O)C3=C2
化学名称 N-((2R)-1,4-Dioxan-2-ylmethyl)-N-methyl-N'-[3-(1-methyl-1H-pyrazol-4-yl)-5-oxo-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl]sulfamide

生物活性

Description
MK-2461, a novel multitargeted kinase inhibitor, preferentially inhibits the activated c-Met receptor.
Targets
Target Value
c-Met(M1250T)IC50: 0.4nM
c-Met(Y1235D)IC50: 0.5nM
c-Met(Y1230H)IC50: 1.0nM
c-Met(N1100)IC50: 1.5nM
c-Met(Y1230C)IC50: 1.5nM
c-MetIC50: 2.5nM
RONIC50: 7nM
FLT1IC50: 10nM
FLT3IC50: 22nM
PDGFRβIC50: 22nM
MerIC50: 24nM
FGFR2IC50: 39nM
KDRIC50: 44nM
TrkAIC50: 46nM
FGFR3IC50: 50nM
TrkBIC50: 61nM
FGFR1IC50: 65nM
FLT4IC50: 78nM
DRAK1IC50: 199nM
JAK2IC50: 225nM
IRAK4IC50: 298nM
MELKIC50: 606nM
RETIC50: 635nM
DYRK2IC50: 1.143μM
MLK1IC50: 4.303μM
IRAK1IC50: 5.459μM
AblIC50: 7.747μM

溶解性

Solubility (25°C) * In vitro DMSO 99 mg/mL (199.77 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 1% DMSO/30% polyethylene glycol/1% Tween 80, pH 4 15 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.18 mL 100.89 mL 201.78mL
0.5 mM 4.04 mL 20.18 mL 40.36 mL
1 mM 2.02 mL 10.09 mL 20.18 mL
5 mM 0.4 mL 2.02 mL 4.04 mL

*The above data is based on the productmolecular weight 495.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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