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MK-5108 (VX-689)


Aurora A Kinase 抑制剂

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产品目录号: A11410


产品名 目录号 价格 数量
MK-5108 5mg A11410-5
¥ 1,000.00
MK-5108 10mg A11410-10
¥ 1,700.00
MK-5108 50mg A11410-50
¥ 4,500.00
MK-5108 100mg A11410-100
¥ 7,500.00
MK-5108 (VX-689) 10mM * 1mL in DMSO A11410-10mM-D
¥ 1,200.00



MK-5108, also known as VX-689, is a competitive inhibitor of the ATP-binding site of aurora A kinase.

MK-5108 (VX-689)




顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 MK-5108 (VX-689) 发表的文献 (1)
  • Wei TW, .et al. Aurora A and NF-百B Survival Pathway Drive Chemoresistance in Acute Myeloid Leukemia via the TRAF-Interacting Protein TIFA, Cancer Res, 2017, Jan 15;77(2):494-508 PMID: 28069801

Chemical Information

目录号 A11410
Mechanism of action Inhibitor
分子量 461.9
化学分子式 C22H21ClFN3O3S
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 1010085-13-8
Synonyms MK5108, VX689
化学名称 trans-4-(3-Chloro-2-fluorophenoxy)-1-[[6-(2-thiazolylamino)-2-pyridinyl]methyl]cyclohexanecarboxylic acid


MK-5108, also known as VX-689, is a competitive inhibitor of the ATP-binding site of aurora A kinase.
Aurora A (Cell-free assay)
0.064 nM


Solubility (25°C) * In vitro DMSO 92 mg/mL (199.16 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 0.5% methylcellulose/0.2% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.


Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.65 mL 108.25 mL 216.5mL
0.5 mM 4.33 mL 21.65 mL 43.3 mL
1 mM 2.16 mL 10.82 mL 21.65 mL
5 mM 0.43 mL 2.16 mL 4.33 mL

*The above data is based on the productmolecular weight 461.9 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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