MK-8245

Name: MK-8245
SKU: A11403

目录号: A11403

SCD 抑制剂

Product Citations (1)

MK-8245 Chemical Structure

CAS NO. 1030612-90-8, 1030612-87-3

MK-8245是肝脏靶向的硬脂酰CoA去饱和酶（SCD）抑制剂。MK-8245可用于治疗糖尿病和血脂异常。

库存：现货

规格	价格	数量
5 mg	￥ 1,100.00
10 mg	￥ 1,700.00
50 mg	￥ 4,850.00
100 mg	￥ 6,750.00
10mM * 1mL in DMSO	￥ 800.00

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生物活性

MK-8245是肝脏靶向的硬脂酰CoA去饱和酶（SCD）抑制剂。MK-8245可用于治疗糖尿病和血脂异常。

靶点信息

SCD1 (human)	SCD1 (rat)	SCD1 (mouse)
1 nM	3 nM	3 nM

溶解度 *

In vitro (25°C)	DMSO	89 mg/mL (190.47 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	1% CMC+0.5% Tween-80	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	21.4 mL	107 mL	214 mL
0.5 mM	4.28 mL	21.4 mL	42.8 mL
1 mM	2.14 mL	10.7 mL	21.4 mL
5 mM	0.43 mL	2.14 mL	4.28 mL

*The above data is based on the productmolecular weight 467.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A11403
作用机制	Inhibitor (抑制剂)
M. Wt	467.3
Formula	C17H16BrFN6O4
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	1030612-90-8, 1030612-87-3
Synonyms	MK8245
SMILES	C1CN(CCC1OC2=C(C=CC(=C2)F)Br)C3=NOC(=C3)C4=NN(N=N4)CC(=O)O