MK-8719

Name: MK-8719
SKU: A18839
Price: 630 CNY
Rating: 5 (288 reviews)

目录号: A18839

OGA 抑制剂

MK-8719 是一种高效且选择性的 OGA 抑制剂（EC50 = 52.7 nM），是治疗 Tauopathies 的潜在疗法。MK-8719 显示出优异的中枢神经系统渗透性，已进入人体第一阶段临床试验。

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Grouped product items
规格	价格	库存
1mg	¥630.00	现货
5mg	¥1,330.00	现货
10mg	¥2,240.00	现货
25mg	¥3,850.00	现货
50mg	¥5,460.00	现货
100mg	¥7,805.00	现货
*10mM 1mL in DMSO**	¥1,995.00	现货
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重要通知：仅供研究使用。我们不向患者销售。

Data Sheet

SDS

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生物活性

Discription	MK-8719 is a highly potent and selective OGA inhibitor (EC50 = 52.7 nM) which is a Potential Treatment for Tauopathies. MK-8719 showed excellent CNS penetration that has been advanced to first-in-human phase I clinical trials.

产品信息

目录号	A18839
分子式	C9H14F2N2O3S
分子量	268.27
CAS号	1382799-40-7
SMILES	O[C@H]1[C@H](O)[C@@]2([H])N=C(NCC)S[C@@]2([H])O[C@@H]1C(F)F
其他名称	MK-8719; MK 8719; MK8719;
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro	DMSO	52 mg/mL (193.83 mM)
	Water	52 mg/mL (193.83 mM)
	Ethanol	52 mg/mL (193.83 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	37.28 mL	186.38 mL	372.76 mL
0.5 mM	7.46 mL	37.28 mL	74.55 mL
1 mM	3.73 mL	18.64 mL	37.28 mL
5 mM	0.75 mL	3.73 mL	7.46 mL

Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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* Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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