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MK-8719

MK-8719

Name: MK-8719
SKU: A18839

目录号: A18839

OGA inhibitor

MK-8719 Chemical Structure

CAS NO. 1382799-40-7

MK-8719 is a highly potent and selective OGA inhibitor (EC50 = 52.7 nM) which is a Potential Treatment for Tauopathies. MK-8719 showed excellent CNS penetration that has been advanced to first-in-human phase I clinical trials.

库存：现货

规格	价格	数量
5 mg	￥ 3,500.00
10 mg	￥ 6,500.00
50 mg	￥ 20,000.00

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产品详情

生物活性

溶解度 *

In vitro	DMSO	52 mg/mL (193.83 mM)
	Water	52 mg/mL (193.83 mM)
	Ethanol	52 mg/mL (193.83 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	37.28 mL	186.38 mL	372.76 mL
0.5 mM	7.46 mL	37.28 mL	74.55 mL
1 mM	3.73 mL	18.64 mL	37.28 mL
5 mM	0.75 mL	3.73 mL	7.46 mL

*The above data is based on the productmolecular weight 268.27. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A18839
作用机制	Inhibitor (抑制剂)
M. Wt	268.27
Formula	C9H14F2N2O3S
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	1382799-40-7
Synonyms	MK-8719; MK 8719; MK8719;
SMILES	O[C@H]1[C@H](O)[C@@]2([H])N=C(NCC)S[C@@]2([H])O[C@@H]1C(F)F