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MK-8745

促销

Aurora Kinase A 抑制剂

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产品目录号: A13396

库存状态:中国现货中国现货

产品名 目录号 价格 数量
MK-8745 10mg A13396-10
¥ 600.00
MK-8745 25mg A13396-25
¥ 1,200.00
MK-8745 50mg A13396-50
¥ 1,800.00
MK-8745 10mM * 1mL in DMSO A13396-10mM-D
¥ 600.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

MK-8745 is a novel Aurora-A specific inhibitor. It induces apoptotic cell death in a p53-dependent manner when tested in vitro in cell lines of multiple lineages.

MK-8745

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Chemical Information

目录号 A13396
Mechanism of action Inhibitor
分子量 431.91
化学分子式 C20H19ClFN5OS
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 885325-71-3
Synonyms MK8745, MK 8745
SMILES code ClC1=C(F)C(C(N2CCN(CC3=NC(NC4=NC=CS4)=CC=C3)CC2)=O)=CC=C1
化学名称 (3-chloro-2-fluorophenyl)(4-((6-(thiazol-2-ylamino)pyridin-2-yl)methyl)piperazin-1-yl)methanone

生物活性

Description
MK-8745 is a novel Aurora-A specific inhibitor. It induces apoptotic cell death in a p53-dependent manner when tested in vitro in cell lines of multiple lineages.
Targets
Aurora A Aurora B
0.6 nM280 nM

溶解性

Solubility (25°C)* In vitro DMSO 86 mg/mL (199.11 mM)
Water <1 mg/mL (<1 mM)
Ethanol 1 mg/mL (2.31 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.15 mL 115.76 mL 231.53mL
0.5 mM 4.63 mL 23.15 mL 46.31 mL
1 mM 2.32 mL 11.58 mL 23.15 mL
5 mM 0.46 mL 2.32 mL 4.63 mL

*The above data is based on the productmolecular weight 431.91. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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