MK-8745

Name: MK-8745
SKU: A13396

目录号: A13396

Aurora Kinase A 抑制剂

MK-8745 Chemical Structure

CAS NO. 885325-71-3

MK-8745是一种新的极光特异性抑制剂。当在多种谱系的细胞系中进行体外试验时，它以p53依赖的方式诱导凋亡细胞死亡。

库存：现货

规格	价格	数量
10 mg	￥ 600.00
25 mg	￥ 1,200.00
50 mg	￥ 1,800.00
10mM * 1mL in DMSO	￥ 600.00

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生物活性

MK-8745是一种新的极光特异性抑制剂。当在多种谱系的细胞系中进行体外试验时，它以p53依赖的方式诱导凋亡细胞死亡。

靶点信息

Aurora A	Aurora B
0.6 nM	280 nM

溶解度 *

In vitro	DMSO	81 mg/mL (187.53 mM)
	Water	Insoluble
	Ethanol	1 mg/mL (2.31 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	23.15 mL	115.76 mL	231.53 mL
0.5 mM	4.63 mL	23.15 mL	46.31 mL
1 mM	2.32 mL	11.58 mL	23.15 mL
5 mM	0.46 mL	2.32 mL	4.63 mL

*The above data is based on the productmolecular weight 431.91. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A13396
作用机制	Inhibitor (抑制剂)
M. Wt	431.91
Formula	C20H19ClFN5OS
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	885325-71-3
Synonyms	MK8745, MK 8745
SMILES	ClC1=C(F)C(C(N2CCN(CC3=NC(NC4=NC=CS4)=CC=C3)CC2)=O)=CC=C1