MK-8745

目录号: A13396

Aurora Kinase A Inhibitor

MK-8745

MK-8745 Chemical Structure

CAS NO. 885325-71-3

MK-8745 is a novel Aurora-A specific inhibitor. It induces apoptotic cell death in a p53-dependent manner when tested in vitro in cell lines of multiple lineages.

库存: 现货

规格 价格 数量
10 mg
¥ 600.00
25 mg
¥ 1,200.00
50 mg
¥ 1,800.00
10mM * 1mL in DMSO
¥ 600.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

详情

MK-8745 is a novel Aurora-A specific inhibitor. It induces apoptotic cell death in a p53-dependent manner when tested in vitro in cell lines of multiple lineages.
Targets
Aurora A Aurora B
0.6 nM280 nM
In vitro DMSO 86 mg/mL (199.11 mM)
Water <1 mg/mL (<1 mM)
Ethanol 1 mg/mL (2.31 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.15 mL 115.76 mL 231.53 mL
0.5 mM 4.63 mL 23.15 mL 46.31 mL
1 mM 2.32 mL 11.58 mL 23.15 mL
5 mM 0.46 mL 2.32 mL 4.63 mL

*The above data is based on the productmolecular weight 431.91. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Technical Details

目录号 A13396
MECHANISM OF ACTION Inhibitor
M. Wt 431.91
Formula C20H19ClFN5OS
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 885325-71-3
Synonyms MK8745, MK 8745
SMILES ClC1=C(F)C(C(N2CCN(CC3=NC(NC4=NC=CS4)=CC=C3)CC2)=O)=CC=C1

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