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ML 786 dihydrochloride是一种有效的Raf激酶抑制剂（B-RafV600E，C-Raf和野生型B-Raf的IC50值分别为2.1、2.5和4.2 nM）。
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 16.35 mL | 81.77 mL | 163.54 mL |
| 0.5 mM | 3.27 mL | 16.35 mL | 32.71 mL |
| 1 mM | 1.64 mL | 8.18 mL | 16.35 mL |
| 5 mM | 0.33 mL | 1.64 mL | 3.27 mL |
*The above data is based on the productmolecular weight 611.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A11211 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 611.48 |
| Formula | C29H29F3N4O3.2HCl |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1237536-18-3 |
| Synonyms | ML786 dihydrochloride |
| SMILES | CC(C)(C1=CC(=CC(=C1)C(=O)NC2CCC3=C(C2)C=C(C=C3)OC4=C5CCC(=O)NC5=NC=C4)C(F)(F)F)N.Cl.Cl |
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