ML348
目录号: A16338
LYPLA1 抑制剂
ML348 是一种选择性和可逆的溶血磷脂酶1（LYPLA1）抑制剂（IC50 = 210 nM），对LYPLA1比LYPLA2具有14倍的选择性。同时，它对约30种其他丝氨酸水解酶也表现出选择性。
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生物活性
| Discription | ML348 is a selective and reversible lysophospholipase 1 (LYPLA1) inhibitor (IC50 = 210 nM), Exhibits 14-fold selectivity for LYPLA1 over LYPLA2, Also selective over a panel of ~30 other serine hydrolases. |
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产品信息
| 目录号 | A16338 |
|---|---|
| 分子式 | C18H17ClF3N3O3 |
| 分子量 | 415.79 |
| CAS号 | 899713-86-1 |
| SMILES | ClC1=C(NC(CN2CCN(C(C3=CC=CO3)=O)CC2)=O)C=C(C(F)(F)F)C=C1 |
| 其他名称 | ML-348, ML 348 |
| 储存条件 | Store lyophilized at -20ºC, keep desiccated. |
溶解性数据
| In vitro | DMSO | 77 mg/mL (185.19 mM) | |
| Water | Insoluble | ||
| Ethanol | 9 mg/mL (21.65 mM) | ||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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Preparing Stock Solutions
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 24.05 mL | 120.25 mL | 240.51 mL |
| 0.5 mM | 4.81 mL | 24.05 mL | 48.1 mL |
| 1 mM | 2.41 mL | 12.03 mL | 24.05 mL |
| 5 mM | 0.48 mL | 2.41 mL | 4.81 mL |
Useful Calculator
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2
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| 购买 899713-86-1 | 899713-86-1 供应商 | 899713-86-1 花费 | 899713-86-1 生产商 | 订购 899713-86-1 | 899713-86-1 代理商