ML367
目录号: A18622
ATAD5 抑制剂
ML367 是一种强效的 ATP酶家族AAA结构域含蛋白5 (ATAD5) 稳定性抑制剂，作为一种探针分子，具有低微摩尔级的抑制活性。ML367 阻断 DNA 修复途径，抑制包括对 UV 辐射响应的 RPA32 磷酸化 和 CHK1 磷酸化 在内的一般 DNA 损伤反应。
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生物活性
| Discription | ML367 is a potent inhibitor of ATPase family AAA domain-containing protein 5 (ATAD5) stabilization, acts as a probe molecule that has low micromolar inhibitory activity. ML367 blocks DNA repair pathways, suppresses general DNA damage responses including RPA32-phosphorylation and CHK1-phosphorylation in response to UV irradiation. |
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产品信息
| 目录号 | A18622 |
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| 分子式 | C19H12F2N4 |
| 分子量 | 334.32 |
| CAS号 | 381168-77-0 |
| SMILES | FC1=CC(NC2=NC(C3=CC=NC=C3)=NC4=CC=CC=C42)=CC=C1F |
| 其他名称 | ML-367, ML 367 |
| 储存条件 | Store lyophilized at -20ºC, keep desiccated. |
溶解性数据
| In vitro | DMSO | 62 mg/mL (185.44 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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Preparing Stock Solutions
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 29.91 mL | 149.56 mL | 299.11 mL |
| 0.5 mM | 5.98 mL | 29.91 mL | 59.82 mL |
| 1 mM | 2.99 mL | 14.96 mL | 29.91 mL |
| 5 mM | 0.6 mL | 2.99 mL | 5.98 mL |
Useful Calculator
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2
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