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Aurora A 抑制剂

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产品目录号: A10601


产品名 目录号 价格 数量
MLN8054 5mg A10601-5
¥ 1,000.00
MLN8054 10mg A10601-10
¥ 1,800.00
MLN8054 50mg A10601-50
¥ 5,600.00
MLN8054 100mg A10601-100
¥ 8,000.00
MLN8054 10mM * 1mL in DMSO A10601-10mM-D
¥ 1,200.00



MLN8054 is an inhibitor of Aurora A kinase, induces senescence in human tumor cells both in vitro and in vivo.





顾客使用 Adooq 产品发表的高质量科研文献

Chemical Information

目录号 A10601
Mechanism of action Inhibitor
分子量 476.9
化学分子式 C25H15ClF2N4O2
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 869363-13-3
Synonyms MLN-8054
SMILES code C1C2=CN=C(N=C2C3=C(C=C(C=C3)Cl)C(=N1)C4=C(C=CC=C4F)F)NC5=CC=C(C=C5)C(=O)O
化学名称 4-[[9-Chloro-7-(2,6-difluorophenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]benzoic acid


MLN8054 is an inhibitor of Aurora A kinase, induces senescence in human tumor cells both in vitro and in vivo.
Target Value
AuroraAIC50: 4nM
AuroraBIC50: 172nM
LCKIC50: 3.2μM
PKAIC50: 19μM
CK2IC50: 20.5μM
Chk2IC50: 28μM
PLK1IC50: 53μM
Chk1IC50: >100μM
PKCIC50: >100μM
CaMKIIIC50: >100μM
CDK2EIC50: >100μM
CDK1IC50: >100μM


Solubility (25°C) * In vitro DMSO 95 mg/mL (199.21 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 15% Captisol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.


Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.97 mL 104.84 mL 209.69mL
0.5 mM 4.19 mL 20.97 mL 41.94 mL
1 mM 2.1 mL 10.48 mL 20.97 mL
5 mM 0.42 mL 2.1 mL 4.19 mL

*The above data is based on the productmolecular weight 476.9 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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