Trusted by 10,000+ Scientists since 2006
微信关注
申请试用装

MLN8054

促销

Aurora A 抑制剂

0 Customer Reviews
产品目录号: A10601

库存状态:中国现货中国现货

产品名 目录号 价格 数量
MLN8054 5mg A10601-5
¥ 1,000.00
MLN8054 10mg A10601-10
¥ 1,800.00
MLN8054 50mg A10601-50
¥ 5,600.00
MLN8054 100mg A10601-100
¥ 8,000.00
MLN8054 10mM * 1mL in DMSO A10601-10mM-D
¥ 1,200.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

MLN8054 is an inhibitor of Aurora A kinase, induces senescence in human tumor cells both in vitro and in vivo.

MLN8054

双击上述图片即可查看完整大小

缩小
放大

更多视图

顾客使用 Adooq 产品发表的高质量科研文献

Chemical Information

目录号 A10601
Mechanism of action Inhibitor
分子量 476.9
化学分子式 C25H15ClF2N4O2
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 869363-13-3
Synonyms MLN-8054
SMILES code C1C2=CN=C(N=C2C3=C(C=C(C=C3)Cl)C(=N1)C4=C(C=CC=C4F)F)NC5=CC=C(C=C5)C(=O)O
化学名称 4-[[9-Chloro-7-(2,6-difluorophenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]benzoic acid

生物活性

Description
MLN8054 is an inhibitor of Aurora A kinase, induces senescence in human tumor cells both in vitro and in vivo.
Targets
Target Value
AuroraAIC50: 4nM
AuroraBIC50: 172nM
LCKIC50: 3.2μM
PKAIC50: 19μM
CK2IC50: 20.5μM
Chk2IC50: 28μM
PLK1IC50: 53μM
Chk1IC50: >100μM
PKCIC50: >100μM
CaMKIIIC50: >100μM
CDK2EIC50: >100μM
CDK1IC50: >100μM

溶解性

Solubility (25°C) * In vitro DMSO 95 mg/mL (199.21 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 15% Captisol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.97 mL 104.84 mL 209.69mL
0.5 mM 4.19 mL 20.97 mL 41.94 mL
1 mM 2.1 mL 10.48 mL 20.97 mL
5 mM 0.42 mL 2.1 mL 4.19 mL

*The above data is based on the productmolecular weight 476.9 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Ordering online

To place an order online, simply browse to the product you are interested in and click on the 'Add to Cart' button. To complete this process, you will need to confirm the size and quantity of the products that you require.

To complete an order you will need to register using our simple online registration process. We do not share your contact details with any third parties.

When you are ready to check out simply enter your PO number to complete the ordering process. Please ensure that you send us a copy of your PO by fax or email afterwards.  We will then liaise with you or your purchasing department to confirm the order.

Found your products but not ready to order?

Why not use our WishList feature to store lists of products? This convenient feature allows you to manage lists, append notes to products and share lists with co-workers or colleagues.

Ordering offline

You can email or fax us your purchase order and we will place the order for you. You can also phone us to place the order.  Our contact details are:

We require the following information to process your order:
  • The catalog number for each product. 
  • Your email address or fax number. 
  • Your name and telephone number. 
  • Shipping address and billing address.
  • Purchase order numbers.

产品标签

使用空格分隔标签。使用单引号(')标注词组。


Keywords:购买 MLN8054 | MLN8054 供应商 | 订购 MLN8054 | MLN8054 价格 | MLN8054 生产商 | 订单 MLN8054 | MLN8054 代理商 | 购买 869363-13-3| 869363-13-3 供应商 | 订购 869363-13-3 | 869363-13-3 价格 | 869363-13-3 生产商 | 订单 869363-13-3 | 869363-13-3 代理商|buy MLN8054 | MLN8054 Supplier | purchase MLN8054 | MLN8054 cost | MLN8054 manufacturer | order MLN8054 | MLN8054 distributor | buy 869363-13-3| 869363-13-3 Supplier | purchase 869363-13-3 | 869363-13-3 cost | 869363-13-3 manufacturer | order 869363-13-3 | 869363-13-3 distributor