MLN8237 (Alisertib)

目录号: A10004

Aurora A Kinase 抑制剂

MLN8237 (Alisertib)

MLN8237 (Alisertib) Chemical Structure

CAS NO. 1028486-01-2

MLN8237 (Alisertib)是一种选择性Aurora A抑制剂,在无细胞分析中的IC50为1.2 nM。它对Aurora A的选择性比Aurora B高200倍以上。

库存: 现货

规格 价格 数量
5 mg
¥ 600.00
10 mg
¥ 1,000.00
50 mg
¥ 2,650.00
200 mg
¥ 7,650.00
10mM * 1mL in DMSO
¥ 800.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

产品详情

MLN8237 (Alisertib)是一种选择性Aurora A抑制剂,在无细胞分析中的IC50为1.2 nM。它对Aurora A的选择性比Aurora B高200倍以上。
In vitro (25°C) DMSO 23 mg/mL (44.32 mM)
Water Insoluble
Ethanol Insoluble
In vivo 5%DMSO+30% PEG300+5%Tween-80+ddH2O 5 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.27 mL 96.36 mL 192.72 mL
0.5 mM 3.85 mL 19.27 mL 38.54 mL
1 mM 1.93 mL 9.64 mL 19.27 mL
5 mM 0.39 mL 1.93 mL 3.85 mL

*The above data is based on the productmolecular weight 518.9. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A10004
作用机制 Inhibitor (抑制剂)
M. Wt 518.9
Formula C27H20ClFN4O4
Purity >99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No. 1028486-01-2
SMILES COC1=C(C(=CC=C1)F)C2=NCC3=CN=C(N=C3C4=C2C=C(C=C4)Cl)NC5=CC(=C(C=C5)C(=O)O)OC

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