MLN8237 (Alisertib)

目录号: A10004

Aurora A Kinase inhibitor

MLN8237 (Alisertib) Chemical Structure

CAS NO. 1028486-01-2

MLN8237(Alisertib)是一种选择性Aurora A抑制剂,在无细胞分析中的IC50为1.2 nM。 它对Aurora A的选择性比Aurora B高200倍以上。

库存: 现货

规格 价格 数量
5 mg
¥ 600.00
10 mg
¥ 1,000.00
50 mg
¥ 2,650.00
200 mg
¥ 7,650.00
10mM * 1mL in DMSO
¥ 800.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

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MLN8237(Alisertib)是一种选择性Aurora A抑制剂,在无细胞分析中的IC50为1.2 nM。 它对Aurora A的选择性比Aurora B高200倍以上。
In vitro (25°C) DMSO 27 mg/mL (52.03 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 15% Captisol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.27 mL 96.36 mL 192.72 mL
0.5 mM 3.85 mL 19.27 mL 38.54 mL
1 mM 1.93 mL 9.64 mL 19.27 mL
5 mM 0.39 mL 1.93 mL 3.85 mL

*The above data is based on the productmolecular weight 518.9. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A10004
MECHANISM OF ACTION Inhibitor
M. Wt 518.9
Formula C27H20ClFN4O4
Solubility DMSO>44mg/mL Water <1mg/mL Ethanol <1mg/mL
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1028486-01-2
Synonyms N/A
SMILES COC1=C(C(=CC=C1)F)C2=NCC3=CN=C(N=C3C4=C2C=C(C=C4)Cl)NC5=CC(=C(C=C5)C(=O)O)OC

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