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MLN8237 (Alisertib)

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Aurora A Kinase 抑制剂

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产品目录号: A10004

库存状态:中国现货中国现货

产品名 目录号 价格 数量
MLN8237 5mg A10004-5
¥ 600.00
MLN8237 10mg A10004-10
¥ 1,000.00
MLN8237 50mg A10004-50
¥ 3,800.00
MLN8237 200mg A10004-200
¥ 9,500.00
MLN8237 (Alisertib) 10mM * 1mL in DMSO A10004-10mM-D
¥ 1,210.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

MLN8237 (Alisertib) 是一种选择性Aurora A抑制剂,无细胞试验中IC50为1.2 nM,作用于Aurora A比作用于Aurora B选择性强200倍以上。Phase 3。

MLN8237 (Alisertib)

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顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 MLN8237 (Alisertib) 发表的文献 (4)
  • Kimura M, .et al. Aurora A regulates the architecture of the Golgi apparatus, Exp Cell Res, 2018, Jun 1;367(1):73-80 PMID: 29571950
  • Jing Wang, .et al. The Aurora-A每Twist1 axis promotes highly aggressive phenotypes in pancreatic carcinoma, J Cell Sci, 2017, Mar 15; 130(6): 1078每1093 PMID: 28167680
  • Lessing D, .et al. A high-throughput small molecule screen identifies synergism between DNA methylation and Aurora kinase pathways for X reactivation, Proc Natl Acad Sci U S A, 2016, Dec 13;113(50):14366-14371 PMID: 28182563
  • Jennifer M. Sahni, .et al. Bromodomain and Extraterminal Protein Inhibition Blocks Growth of Triple-negative Breast Cancers through the Suppression of Aurora Kinases, J Biol Chem, 2016, Nov 4; 291(45): 23756每23768 PMID: 27650498

Chemical Information

目录号 A10004
Mechanism of action Inhibitor
分子量 518.9
化学分子式 C27H20ClFN4O4
Solubility DMSO>44mg/mL Water <1mg/mL Ethanol <1mg/mL
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 1028486-01-2
Synonyms N/A
SMILES code COC1=C(C(=CC=C1)F)C2=NCC3=CN=C(N=C3C4=C2C=C(C=C4)Cl)NC5=CC(=C(C=C5)C(=O)O)OC
化学名称 4-[[9-Chloro-7-(2-fluoro-6-methoxyphenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]-2-methoxybenzoic acid

生物活性

Description
MLN8237 (Alisertib) 是一种选择性Aurora A抑制剂,无细胞试验中IC50为1.2 nM,作用于Aurora A比作用于Aurora B选择性强200倍以上。Phase 3。

溶解性

Solubility (25°C) * In vitro DMSO 27 mg/mL (52.03 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 15% Captisol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.27 mL 96.36 mL 192.72mL
0.5 mM 3.85 mL 19.27 mL 38.54 mL
1 mM 1.93 mL 9.64 mL 19.27 mL
5 mM 0.39 mL 1.93 mL 3.85 mL

*The above data is based on the productmolecular weight 518.9. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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