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Monomethyl auristatin E

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产品目录号: A12954

库存状态:中国现货中国现货

产品名 目录号 价格 数量
Monomethyl auristatin E 5mg A12954-5
¥ 1,900.00
Monomethyl auristatin E 10mg A12954-10
¥ 3,000.00
Monomethyl auristatin E 25mg A12954-25
¥ 5,000.00
Monomethyl auristatin E 50mg A12954-50
¥ 8,500.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

Monomethyl auristatin E (MMAE) is an antimitotic agent which inhibits cell division by blocking the polymerisation of tubulin, and also shows inhibition of antibody-drug conjugates (ADCs) activity.

Monomethyl auristatin E

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顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 Monomethyl auristatin E 发表的文献 (1)
  • Sochaj-Gregorczyk AM, .et al. A Novel Affibody-Auristatin E Conjugate With a Potent and Selective Activity Against HER2+ Cell Lines, J Immunother, 2016, Jul-Aug;39(6):223-32 PMID: 27227324

Chemical Information

目录号 A12954
Mechanism of action Stimulator
分子量 717.98
化学分子式 C39H67N5O7
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 474645-27-7
Synonyms Monomethylauristatin E, MMAE
SMILES code CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@@H]([C@@H](C)C(=O)N[C@H](C)[C@H](C2=CC=CC=C2)O)OC)OC)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](C(C)C)NC
化学名称 N-Methyl-L-valyl-N-[(1S,2R)-4-[(2S)-2-[(1R,2R)-3-[[(1R,2S)-2-hydroxy-1-methyl-2-phenylethyl]amino]-1-methoxy-2-methyl-3-oxopropyl]-1-pyrrolidinyl]-2-methoxy-1-[(1S)-1-methylpropyl]-4-oxobutyl]-N-methyl-L-valinamide

生物活性

Description
Monomethyl auristatin E (MMAE) is an antimitotic agent which inhibits cell division by blocking the polymerisation of tubulin, and also shows inhibition of antibody-drug conjugates (ADCs) activity.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 13.93 mL 69.64 mL 139.28mL
0.5 mM 2.79 mL 13.93 mL 27.86 mL
1 mM 1.39 mL 6.96 mL 13.93 mL
5 mM 0.28 mL 1.39 mL 2.79 mL

*The above data is based on the productmolecular weight 717.98. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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