Motesanib (AMG706) Chemical Structure

CAS NO. 453562-69-1

Motesanib (AMG706) is a multikinase inhibitor that selectively targets VEGF receptors, platelet-derived growth factor receptors (PDGFRs), and Kit receptors with IC?? values of 2 nM (VEGFR1), 3 nM (VEGFR2), 6 nM (VEGFR3), 84 nM (PDGFR), and 8 nM (Kit).

库存: 现货

规格 价格 数量
5 mg
¥ 400.00
10 mg
¥ 500.00
25 mg
¥ 900.00
50 mg
¥ 1,600.00
10mM * 1mL in DMSO
¥ 500.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

详情

Motesanib (AMG706) is a multikinase inhibitor that selectively targets VEGF receptors, platelet-derived growth factor receptors (PDGFRs), and Kit receptors with IC?? values of 2 nM (VEGFR1), 3 nM (VEGFR2), 6 nM (VEGFR3), 84 nM (PDGFR), and 8 nM (Kit).
In vitro (25°C) DMSO 100 mg/mL heating (175.61 mM)
Water 19 mg/mL heating (33.36 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo Saline 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 26.78 mL 133.89 mL 267.77 mL
0.5 mM 5.36 mL 26.78 mL 53.55 mL
1 mM 2.68 mL 13.39 mL 26.78 mL
5 mM 0.54 mL 2.68 mL 5.36 mL

*The above data is based on the productmolecular weight 373.45. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A11496
MECHANISM OF ACTION Inhibitor
M. Wt 373.45
Formula C22H23N5O
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 453562-69-1
Synonyms AMG 706, AMG-706
SMILES CC1(CNC2=C1C=CC(=C2)NC(=O)C3=C(N=CC=C3)NCC4=CC=NC=C4)C

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