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Motesanib Diphosphate (AMG-706)

VEGFR 抑制剂

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产品目录号: A10608

库存状态:中国现货中国现货

产品名 目录号 价格 数量
Motesanib Diphosphate 5mg A10608-5
¥ 300.00
Motesanib Diphosphate 10mg A10608-10
¥ 500.00
Motesanib Diphosphate 50mg A10608-50
¥ 1,600.00
Motesanib Diphosphate 100mg A10608-100
¥ 2,800.00
Motesanib Diphosphate 10mM * 1mL in DMSO A10608-10mM-D
¥ 500.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

Motesanib, also known as AMG-706, is an orally administered multikinase inhibitor that selectively targets VEGF receptors, platelet-derived growth factor receptors, and Kit receptors.

Motesanib Diphosphate (AMG-706)

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Chemical Information

目录号 A10608
Mechanism of action Inhibitor
分子量 569.4
化学分子式 C22H23N5O.2H3PO4
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 857876-30-3
Synonyms AMG-706
SMILES code CC1(CNC2=C1C=CC(=C2)NC(=O)C3=C(N=CC=C3)NCC4=CC=NC=C4)C.OP(=O)(O)O.OP(=O)(O)O
化学名称 N-(2,3-Dihydro-3,3-dimethyl-1H-indol-6-yl)-2-[(4-pyridinylmethyl)amino]-3-pyridinecarboxamide diphosphate

生物活性

Description
Motesanib, also known as AMG-706, is an orally administered multikinase inhibitor that selectively targets VEGF receptors, platelet-derived growth factor receptors, and Kit receptors.
Targets
Target Value
VEGFR1IC50: 2nM
VEGFR2IC50: 3nM
VEGFR2/Flk1IC50: 6nM
VEGFR3IC50: 6nM
KitIC50: 8nM
RETIC50: 59nM
PDGFRIC50: 84nM
FGFRIC50: >2.8μM
EGFRIC50: >3μM
SrcIC50: >3μM
p38IC50: >3μM

溶解性

Solubility (25°C) * In vitro DMSO 100 mg/mL heating (175.61 mM)
Water 19 mg/mL heating (33.36 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo Saline 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 17.56 mL 87.81 mL 175.62mL
0.5 mM 3.51 mL 17.56 mL 35.12 mL
1 mM 1.76 mL 8.78 mL 17.56 mL
5 mM 0.35 mL 1.76 mL 3.51 mL

*The above data is based on the productmolecular weight 569.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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