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MRK 560

??-secretase 抑制剂

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产品目录号: A15304

库存状态:中国现货中国现货

产品名 目录号 价格 数量
MRK 560 10mg A15304-10
¥ 1,700.00
MRK 560 50mg A15304-50
¥ 7,600.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

MRK 560 is an orally bioavailable gamma-secretase inhibitor with the ability to markedly reduce Abeta peptide in the brain and CSF of the rat and confirm the utility of the rat for assessing the effects of gamma-secretase inhibitors on central nervous system Abeta(40) levels in vivo.

MRK 560

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Chemical Information

目录号 A15304
Mechanism of action Inhibitor
分子量 517.92
化学分子式 C19H17ClF5NO4S2
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 677772-84-8
Synonyms MRK-560, MRK560
SMILES code C1CC(CCC1NS(=O)(=O)C(F)(F)F)(C2=C(C=CC(=C2)F)F)S(=O)(=O)C3=CC=C(C=C3)Cl
化学名称 N-((1r,4r)-4-((4-chlorophenyl)sulfonyl)-4-(2,5-difluorophenyl)cyclohexyl)-1,1,1-trifluoromethanesulfonamide

生物活性

Description
MRK 560 is an orally bioavailable gamma-secretase inhibitor with the ability to markedly reduce Abeta peptide in the brain and CSF of the rat and confirm the utility of the rat for assessing the effects of gamma-secretase inhibitors on central nervous system Abeta(40) levels in vivo.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.31 mL 96.54 mL 193.08mL
0.5 mM 3.86 mL 19.31 mL 38.62 mL
1 mM 1.93 mL 9.65 mL 19.31 mL
5 mM 0.39 mL 1.93 mL 3.86 mL

*The above data is based on the productmolecular weight 517.92. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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