MRTX1257
目录号: A17223
KRAS-G12C 抑制剂
MRTX1257 是一种强效、选择性、共价和不可逆的 KRAS G12C 抑制剂，MRTX1257 在 H358 细胞实验中抑制 KRAS 依赖的 ERK磷酸化，IC50 值为 900 pM。
顾客使用 Adooq 产品发表的高质量科研文献
生物活性
| Discription | MRTX1257 is a potent, selective, covalent and irreversible inhibitor of KRAS G12C, MRTX1257 inhibited KRAS dependent ERKphosphorylation in the H358cell assay with an IC50= 900 pM. | |||||
|---|---|---|---|---|---|---|
| Targets |
|
|||||
| Cell Research |
|
产品信息
| 目录号 | A17223 |
|---|---|
| 分子式 | C33H39N7O2 |
| 分子量 | 565.722 |
| CAS号 | 2206736-04-9 |
| SMILES | N#CC[C@@H]1N(C(C=C)=O)CCN(C2=C3C(CN(C4=C5C(C)=CC=CC5=CC=C4)CC3)=NC(OC[C@H]6N(C)CCC6)=N2)C1 |
| 其他名称 | MRTX-1257; MRTX 1257; |
| 储存条件 | Store lyophilized at -20ºC, keep desiccated. |
溶解性数据
| In vitro | DMSO | 89 mg/mL (157.32 mM) | |
| Water | Insoluble | ||
| Ethanol | 27 mg/mL | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
Preparing Stock Solutions
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 17.68 mL | 88.38 mL | 176.77 mL |
| 0.5 mM | 3.54 mL | 17.68 mL | 35.35 mL |
| 1 mM | 1.77 mL | 8.84 mL | 17.68 mL |
| 5 mM | 0.35 mL | 1.77 mL | 3.54 mL |
Useful Calculator
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2
Keywords: 购买 MRTX1257 | MRTX1257 供应商 | MRTX1257 花费 | MRTX1257 生产商 | 订购 MRTX1257 | MRTX1257 代理商
| 购买 2206736-04-9 | 2206736-04-9 供应商 | 2206736-04-9 花费 | 2206736-04-9 生产商 | 订购 2206736-04-9 | 2206736-04-9 代理商