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MS-275 (Entinostat)

促销

HDAC 抑制剂

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产品目录号: A10611

库存状态:中国现货中国现货

产品名 目录号 价格 数量
MS-275 10mg A10611-10
¥ 400.00
MS-275 25mg A10611-25
¥ 700.00
MS-275 50mg A10611-50
¥ 900.00
MS-275 200mg A10611-200
¥ 1,900.00
MS-275 (Entinostat) 10mM * 1mL in DMSO A10611-10mM-D
¥ 500.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

MS-275 (Entinostat) is a potent HDAC inhibitor with IC50 of 0.3 and 8uM for HDAC1 and HDAC3, respectively.

MS-275 (Entinostat)

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顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 MS-275 (Entinostat) 发表的文献 (1)
  • Minoru Ueda, .et al. The Distinct Roles of Class I and II RPD3-Like Histone Deacetylases in Salinity Stress Response, Plant Physiol, 2017, Dec; 175(4): 1760每1773 PMID: 29018096

Chemical Information

目录号 A10611
Mechanism of action Inhibitor
分子量 376.4
化学分子式 C21H20N4O3
Solubility DMSO>75mg/mL Water<1mg/mL Ethanol<1mg/mL
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 209783-80-2
Synonyms SNDX-275
SMILES code C1=CC=C(C(=C1)N)NC(=O)C2=CC=C(C=C2)CNC(=O)OCC3=CN=CC=C3
化学名称 Pyridin-3-ylmethyl N-[[4-[(2-aminophenyl)carbamoyl]phenyl]methyl]carbamat

生物活性

Description
MS-275 (Entinostat) is a potent HDAC inhibitor with IC50 of 0.3 and 8uM for HDAC1 and HDAC3, respectively.
Targets
HDAC1 (Cell-free assay) HDAC3 (Cell-free assay)
0.51 μM1.7 μM

溶解性

Solubility (25°C) * In vitro DMSO 75 mg/mL (199.25 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% propylene glycol, 5% Tween 80, 65% D5W 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 26.57 mL 132.84 mL 265.67mL
0.5 mM 5.31 mL 26.57 mL 53.13 mL
1 mM 2.66 mL 13.28 mL 26.57 mL
5 mM 0.53 mL 2.66 mL 5.31 mL

*The above data is based on the productmolecular weight 376.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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