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MS402 is a BD1-selective BET BrD inhibitor with Kis of 77 nM, 718 nM, 110 nM, 200 nM, 83 nM, and 240 nM for BRD4(BD1), BRD4(BD2), BRD3(BD1), BRD3(BD2), BRD2(BD1) and BRD2(BD2), respectively.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 26.97 mL | 134.83 mL | 269.67 mL |
| 0.5 mM | 5.39 mL | 26.97 mL | 53.93 mL |
| 1 mM | 2.7 mL | 13.48 mL | 26.97 mL |
| 5 mM | 0.54 mL | 2.7 mL | 5.39 mL |
*The above data is based on the productmolecular weight 370.83. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A18866 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 370.83 |
| Formula | C20H19ClN2O3 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1672684-68-2 |
| Synonyms | MS-402, MS 402 |
| SMILES | O=C(NC1=CC=C(OC)C=C1)C2=CC=C(NC3=C(C)C(CC3)=O)C(Cl)=C2 |
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