Murlentamab (3C23K; GM102) is a humanized monoclonal antibody targeting AMHRII, the anti-M??llerian hormone receptor II. This antibody plays a crucial role in enhancing macrophage-mediated antibody-dependent cell-mediated cytotoxicity (ADCC), a key mechanism in immune defense against tumors. Murlentamab facilitates the creation of a pro-inflammatory and anti-tumor microenvironment, effectively recruiting and activating T cells. Additionally, it inhibits tumor growth by directing the differentiation of na??ve macrophages and reprogramming tumor-associated macrophages (TAMs) towards phenotypes that support tumor eradication. This makes Murlentamab a valuable tool for research in cancer immunotherapy and macrophage biology.
Murlentamab (3C23K; GM102) is a humanized monoclonal antibody targeting AMHRII, the anti-M??llerian hormone receptor II. This antibody plays a crucial role in enhancing macrophage-mediated antibody-dependent cell-mediated cytotoxicity (ADCC), a key mechanism in immune defense against tumors. Murlentamab facilitates the creation of a pro-inflammatory and anti-tumor microenvironment, effectively recruiting and activating T cells. Additionally, it inhibits tumor growth by directing the differentiation of na??ve macrophages and reprogramming tumor-associated macrophages (TAMs) towards phenotypes that support tumor eradication. This makes Murlentamab a valuable tool for research in cancer immunotherapy and macrophage biology.
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