Napabucasin
目录号: A13474
STAT 抑制剂
Napabucasin 是一种口服小分子药物,能够阻断癌症干细胞(CSC)的自我更新,并诱导癌症干细胞及非干细胞癌细胞的死亡。
| Discription | Napabucasin is an orally-administered small molecule which can block cancer stem cell (CSC) self-renewal and induces cell death in CSCs as well as non-stem cancer cells. | |||||
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| 目录号 | A13474 |
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| 分子式 | C14H8O4 |
| 分子量 | 240.21 |
| CAS号 | 83280-65-3 |
| SMILES | O=C(C1=C2OC(C(C)=O)=C1)C3=C(C2=O)C=CC=C3 |
| 其他名称 | BBI 608, BBI608, BBI-608 |
| 储存条件 | Store lyophilized at -20ºC, keep desiccated. |
| In vitro (25°C) | DMSO | 10 mg/mL (41.63 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
| In vivo | 5% DMSO+40% PEG 300+5% Tween 80+ddH2O | 1 mg/mL | |
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 41.63 mL | 208.15 mL | 416.3 mL |
| 0.5 mM | 8.33 mL | 41.63 mL | 83.26 mL |
| 1 mM | 4.16 mL | 20.82 mL | 41.63 mL |
| 5 mM | 0.83 mL | 4.16 mL | 8.33 mL |
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2