Naquotinib mesylate
目录号: A20762
EGFR 抑制剂
Naquotinib mesylate (ASP8273 mesylate) 是一种口服可用的、突变选择性的、不可逆的 EGFR 抑制剂;对 EGFR 突变体 的 IC50 为 8-33 nM,对 EGFR 的 IC50 为 230 nM。
Discription | Naquotinib mesylate (ASP8273 mesylate) is an orally available, mutant-selective and irreversible EGFR inhibitor; with IC50s of 8-33 nM toward EGFR mutants and 230 nM for EGFR. | ||
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目录号 | A20762 |
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分子式 | C31H46N8O6S |
分子量 | 658.81 |
CAS号 | 1448237-05-5 |
SMILES | O=C(C1=NC(CC)=C(O[C@H]2CN(C(C=C)=O)CC2)N=C1NC3=CC=C(N4CCC(N5CCN(C)CC5)CC4)C=C3)N.CS(=O)(O)=O |
其他名称 | ASP8273 (mesylate), ASP 8273, ASP-8273 |
储存条件 | Store lyophilized at -20ºC, keep desiccated. |
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2