Natalizumab is a recombinant, humanized IgG4 monoclonal antibody that targets ??4??1-integrin, effectively inhibiting its interaction with vascular cell adhesion molecule-1 (VCAM-1). This antibody is utilized in the management of relapsing-remitting multiple sclerosis and Crohn's disease. It represents the inaugural targeted therapeutic approach that impedes lymphocyte migration into the central nervous system (CNS), thereby preventing acute demyelinating episodes.
Natalizumab is a recombinant, humanized IgG4 monoclonal antibody that targets ??4??1-integrin, effectively inhibiting its interaction with vascular cell adhesion molecule-1 (VCAM-1). This antibody is utilized in the management of relapsing-remitting multiple sclerosis and Crohn's disease. It represents the inaugural targeted therapeutic approach that impedes lymphocyte migration into the central nervous system (CNS), thereby preventing acute demyelinating episodes.
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