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Necrostatin-1

促销

RIPK1 抑制剂

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产品目录号: A11973

库存状态:中国现货中国现货

产品名 目录号 价格 数量
Necrostatin-1 10mg A11973-10
¥ 500.00
Necrostatin-1 25mg A11973-25
¥ 900.00
Necrostatin-1 50mg A11973-50
¥ 1,500.00
Necrostatin-1 10mM * 1mL in DMSO A11973-10mM-D
¥ 500.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

Necrostatin-1 is an ATP-competitive, allosteric inhibitor of receptor-interacting protein kinase 1 (RIPK1) (EC50 = 182 nM).

Necrostatin-1

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Chemical Information

目录号 A11973
Mechanism of action Inhibitor
分子量 259.33
化学分子式 C13H13N3OS
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 4311-88-0
Synonyms N/A
SMILES code CN1C(=O)C(NC1=S)CC2=CNC3=CC=CC=C32
化学名称 5-(1H-Indol-3-ylmethyl)-3-methyl-2-?thioxo-4-imidazolidinone

生物活性

Description
Necrostatin-1 is an ATP-competitive, allosteric inhibitor of receptor-interacting protein kinase 1 (RIPK1) (EC50 = 182 nM).
Targets
RIP1 (293T cells)
490 nM(EC50)

溶解性

Solubility (25°C)* In vitro DMSO 52 mg/mL (200.51 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 38.56 mL 192.8 mL 385.61mL
0.5 mM 7.71 mL 38.56 mL 77.12 mL
1 mM 3.86 mL 19.28 mL 38.56 mL
5 mM 0.77 mL 3.86 mL 7.71 mL

*The above data is based on the productmolecular weight 259.33. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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