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Nelarabine (Arranon)

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产品目录号: A10632

库存状态:中国现货中国现货

产品名 目录号 价格 数量
Nelarabine (Arranon) 5mg A10632-5
¥ 700.00
Nelarabine (Arranon) 10mg A10632-10
¥ 1,200.00
Nelarabine (Arranon) 50mg A10632-50
¥ 4,000.00
Nelarabine (Arranon) 100mg A10632-100
¥ 7,000.00
Nelarabine (Arranon) 10mM * 1mL in DMSO A10632-10mM-D
¥ 800.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

Nelarabine is a purine nucleoside analog converted to its corresponding arabinosylguanine nucleotide triphosphate (araGTP), resulting in inhibition of DNA synthesis and cytotoxicity.

Nelarabine (Arranon)

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Chemical Information

目录号 A10632
Mechanism of action N/A
分子量 297.3
化学分子式 C11H15N5O5
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 121032-29-9
Synonyms 506U78
SMILES code COC1=NC(=NC2=C1N=CN2[C@H]3[C@H]([C@@H]([C@H](O3)CO)O)O)N
化学名称 (2R,3S,4R,5R)-2-(2-amino-6-methoxy-purin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol

生物活性

Description
Nelarabine is a purine nucleoside analog converted to its corresponding arabinosylguanine nucleotide triphosphate (araGTP), resulting in inhibition of DNA synthesis and cytotoxicity.
Targets
DNA synthesis (PER-255 cells) DNA synthesis (HSB2 cells) DNA synthesis (ALL-SIL cells) DNA synthesis (JURKAT cells)
67 nM0.44 μM1.24 μM2.15 μM

溶解性

Solubility (25°C) * In vitro DMSO 60 mg/mL (201.83 mM)
Water 3 mg/mL (10.09 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 1% DMSO/30% polyethylene glycol/1% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 33.64 mL 168.18 mL 336.36mL
0.5 mM 6.73 mL 33.64 mL 67.27 mL
1 mM 3.36 mL 16.82 mL 33.64 mL
5 mM 0.67 mL 3.36 mL 6.73 mL

*The above data is based on the productmolecular weight 297.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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