Netupitant
目录号: A14428
NK1 receptor 拮抗剂
Netupitant 是一种选择性神经激肽1（NK1）受体拮抗剂。它与人体物质P/NK1受体竞争性结合，并阻断中枢神经系统（CNS）中的活性，从而抑制内源性缓激肽神经肽物质P（SP）与NK1受体的结合，这可能有助于预防化疗引起的恶心和呕吐（CINV）。
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生物活性
| Discription | Netupitant is a selective neurokinin 1 (NK1) receptor antagonist. It competitively binds to and blocks the activity of the human substance P/NK1 receptors in the central nervous system (CNS), thereby inhibiting NK1-receptor binding of the endogenous tachykinin neuropeptide substance P (SP), which may result in the prevention of chemotherapy-induced nausea and vomiting (CINV). | ||
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产品信息
| 目录号 | A14428 |
|---|---|
| 分子式 | C30H32F6N4O |
| 分子量 | 578.59 |
| CAS号 | 290297-26-6 |
| SMILES | CC1=CC=CC=C1C2=CC(=NC=C2N(C)C(=O)C(C)(C)C3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F)N4CCN(CC4)C |
| 其他名称 | D05152, AG-E-94200 |
| 储存条件 | Store lyophilized at -20ºC, keep desiccated. |
溶解性数据
| In vitro | DMSO | 2 mg/mL (3.45 mM) | |
| Water | Insoluble | ||
| Ethanol | 85 mg/mL (146.91 mM) | ||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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Preparing Stock Solutions
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 17.28 mL | 86.42 mL | 172.83 mL |
| 0.5 mM | 3.46 mL | 17.28 mL | 34.57 mL |
| 1 mM | 1.73 mL | 8.64 mL | 17.28 mL |
| 5 mM | 0.35 mL | 1.73 mL | 3.46 mL |
Useful Calculator
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2
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| 购买 290297-26-6 | 290297-26-6 供应商 | 290297-26-6 花费 | 290297-26-6 生产商 | 订购 290297-26-6 | 290297-26-6 代理商