Netupitant

目录号: A14428

NK1 receptor 拮抗剂

Netupitant

Netupitant Chemical Structure

CAS NO. 290297-26-6

Netupitant是一种选择性的神经激肽1(NK1)受体拮抗剂。它竞争性地结合并阻断中枢神经系统(CNS)中人类物质P/NK1受体的活性,从而抑制内源性速激肽神经肽物质P(SP)的NK1受体结合,这可能导致预防化疗引起的恶心和呕吐(CINV)。

库存: 现货

规格 价格 数量
5 mg
¥ 400.00
10 mg
¥ 700.00
25 mg
¥ 1,500.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

产品详情

Netupitant是一种选择性的神经激肽1(NK1)受体拮抗剂。它竞争性地结合并阻断中枢神经系统(CNS)中人类物质P/NK1受体的活性,从而抑制内源性速激肽神经肽物质P(SP)的NK1受体结合,这可能导致预防化疗引起的恶心和呕吐(CINV)。
靶点信息
neurokinin 1 receptor
In vitro DMSO 2 mg/mL (3.45 mM)
Water Insoluble
Ethanol 85 mg/mL (146.91 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 17.28 mL 86.42 mL 172.83 mL
0.5 mM 3.46 mL 17.28 mL 34.57 mL
1 mM 1.73 mL 8.64 mL 17.28 mL
5 mM 0.35 mL 1.73 mL 3.46 mL

*The above data is based on the productmolecular weight 578.59. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A14428
作用机制 Antagonist (拮抗剂)
M. Wt 578.59
Formula C30H32F6N4O
Purity >99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No. 290297-26-6
Synonyms D05152, AG-E-94200
SMILES CC1=CC=CC=C1C2=CC(=NC=C2N(C)C(=O)C(C)(C)C3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F)N4CCN(CC4)C

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